ASIC1a介导类风湿关节炎软骨细胞损伤机制的研究进展

doi:10.11958/20240017

天津医药 ›› 2024, Vol. 52 ›› Issue (9): 1004-1008.doi: 10.11958/20240017

• 综述 • 上一篇

ASIC1a介导类风湿关节炎软骨细胞损伤机制的研究进展

钟玉梅¹(), 周海燕², 张敏¹^,^△()

1 成都市第一人民医院/成都中医药大学附属中西医结合医院（邮编610041）
2 成都中医药大学针灸推拿学院

收稿日期:2024-01-03 修回日期:2024-01-23 出版日期:2024-09-15 发布日期:2024-09-06
通讯作者: ^△E-mail：1079954892@qq.com
作者简介:钟玉梅（1991），女，主治医师，主要从事针灸治疗类风湿关节炎的机制方面研究。E-mail：704755938@qq.com
基金资助:
四川省自然科学基金青年项目(2023NSFSC1823);四川中医药文化协同发展研究中心一般项目(2022XT73);国家自然科学基金面上项目(81973959)

Research progress on the mechanism of ASIC1a-mediated chondrocyte injury in rheumatoid arthritis

ZHONG Yumei¹(), ZHOU Haiyan², ZHANG Min¹^,^△()

1 Chengdu First People’s Hospital /Chengdu Integrated TCM & Western Medicine Hospital Affiliated to Chengdu University of Traditional Chinese Medicine, Chengdu 610041, China
2 College of Acupuncture and Massage, Chengdu University of Traditional Chinese Medicine

Received:2024-01-03 Revised:2024-01-23 Published:2024-09-15 Online:2024-09-06
Contact: ^△E-mail：1079954892@qq.com

钟玉梅, 周海燕, 张敏. ASIC1a介导类风湿关节炎软骨细胞损伤机制的研究进展[J]. 天津医药, 2024, 52(9): 1004-1008.

ZHONG Yumei, ZHOU Haiyan, ZHANG Min. Research progress on the mechanism of ASIC1a-mediated chondrocyte injury in rheumatoid arthritis[J]. Tianjin Medical Journal, 2024, 52(9): 1004-1008.

摘要/Abstract

摘要：

类风湿关节炎（RA）是临床难治性自身免疫性疾病，骨破坏是RA中晚期的主要病理特征。酸敏感离子通道1a（ASIC1a）是细胞外H⁺激活的阳离子通道家族的一员，可将细胞外微环境的低pH信号传递至细胞内，激活下游信号通路，诱导一系列的病理变化。ASIC1a在RA发病中具有关键的作用，可促进关节炎症、滑膜增生、骨及关节软骨的破坏，在RA病理过程中具有重要意义。就ASIC1a的分子特性进行概述，并重点关注其改善RA软骨损伤的可能机制，为治疗RA提供新的思路。

关键词: 关节炎, 类风湿, 软骨细胞, 酸敏感离子通道, 细胞凋亡, 细胞外酸化

Abstract:

Rheumatoid arthritis (RA) is a clinically refractory autoimmune disease. The destruction of bone and articular cartilage is a key pathological feature in the middle and late stages of RA. Acid-sensing ion channel 1a (ASIC1a) is a member of extracellular H⁺ activated cation channel family, which can transmit low pH signal from extracellular microenvironment into cells, activate downstream pathways and induce a series of pathological changes. New evidence shows that ASIC1a plays a key role in the pathogenesis of RA, promoting joint inflammation, synovial hyperplasia and the destruction of bone and articular cartilage, which is of great significance in the pathological process of disease. In this paper, the molecular characteristics of ASIC1a are briefly reviewed, and the possible mechanism of ASIC1a to improve cartilage injury of RA is emphasized, so as to provide new ideas for the treatment of RA.

Key words: arthritis, rheumatoid, chondrocytes, acid sensing ion channels, apoptosis, extracellular acidification

中图分类号:

R593.22

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ASIC1a介导类风湿关节炎软骨细胞损伤机制的研究进展

Research progress on the mechanism of ASIC1a-mediated chondrocyte injury in rheumatoid arthritis

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