天津医药

• 临床论丛 •    

药物过敏反应猝死尸检分析

杨霞   

  1. 天津市胸科医院
  • 收稿日期:2010-05-21 修回日期:2010-08-01 出版日期:2010-09-15 发布日期:2010-09-15
  • 通讯作者: 杨霞

The pathological study on sudden death of anaphylaxis

  • Received:2010-05-21 Revised:2010-08-01 Published:2010-09-15 Online:2010-09-15

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摘要： 摘要 目的：探讨医疗纠纷尸检中药物过敏性猝死特点和病理诊断要求。方法:对我院2002年—2010年尸检检出的10例药物过敏性病例进行回顾性分析。结果：10例药物过敏的死者年龄为18—88岁，平均年龄47岁，5例为头孢类抗生素药物过敏，占50%，且多发生在个体诊所和基层医院。病理解剖可见喉头粘膜水肿6例，肺水肿9例，甲苯胺蓝染色见肥大细胞脱颗粒现象7例。结论：药物过敏性猝死诊断应结合患者生前临床表现、病史、解剖所见和肥大细胞脱颗粒现象综合分析。

关键词: 药物过敏反应, 尸检, 肥大细胞

Abstract: Abstract：Objective: study on the characteristics of died-cases with allergic shook in Autopsy and their pathological diagnosis criteris. Methods: Review study 10 autopsy cases in our department between 2002 to 2010.Results: 10 cases were between 18 to 88 years old .The most common reason resulting in anaphylaxis was Cephalosporin. The allergic cases usually happen at the private clinics and the base hospitals .The edema of throat of 6cases was found in Autopsy, 9cases were acute pulmonary edema, there were 7cases with mast cell releasing granules .Conclusion: sudden death of anaphylaxis should synchronously consider clinical symptoms, history, observation in autopsy and most cell releasing granules.

Key words: Anaphylaxis , autopsy, mast cell