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食欲素A与慢性阻塞性肺疾病患者呼吸中枢驱动的相关性研究

秦勇1,李峰1,赵恬2   

  1. 1. 新疆生产建设兵团第一师医院
    2. 浙江医院
  • 收稿日期:2013-10-24 修回日期:2014-03-20 出版日期:2014-08-15 发布日期:2014-08-15
  • 通讯作者: 赵恬

The Relationship between Orexin A and Respiratory Drive in Patients with Chronic Obstructive Pulmonary Disease

QIN Yong , LI Feng ,ZHAO Tian   

  • Received:2013-10-24 Revised:2014-03-20 Published:2014-08-15 Online:2014-08-15
  • Contact: ZHAO Tian

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摘要： 摘要： 目的： 探讨食欲素A水平与COPD患者呼吸中枢驱动之间的关系。 方法： 收集稳定期COPD30例，以及健康对照者20例。记录所有受试者体重指数（BMI），年龄，以及COPD组患者吸烟史。采血测定血浆食欲素A水平的。所有受试者均于采血当天上午测定肺功能，主要测定指标为第一秒用力呼气容积（FEV1）、用力肺活量（FVC）和FEV1/FVC，以及最大呼气压（MEP）、最大吸气压（MIP）、口腔闭合压（P0.1）。结果： COPD组患者血浆食欲素A水平（1.87±0.43）ng/L高于健康对照组（1.49±0.19）ng/L，P< 0.01。COPD组患者血浆食欲素A与FEV1呈负相关（r=-0.389，P<0.05），与P0.1呈正相关（r=0.728，P< 0.01），与年龄、BMI、MEP、MIP均无相关性（r=-0.025、0.183、-0.258、0.026，P均> 0.05）。结论： COPD患者血浆食欲素A水平升高，其原因可能与吸烟和高碳酸血症有关，且食欲素A可能参与COPD呼吸中枢驱动的调节。

关键词: 肺疾病, 慢性阻塞性, 呼吸功能试验, 呼吸中枢, 食欲素A

Abstract: Abstract Obejective: To explore the correlation of respiratory drive with orexin A in COPD patients. Methods: Pulmonary function test was performed in 30 patients with stable COPD and 20 normal healthy adults. The level of plasma orexin-A was measured with a radioimmunoassay kit. The correlation of orexin A with BMI, age, BDI, FEV1, FVC, FEV1/FVC, MEP, MIP, P0.1 in COPD patients was analyzed. Results: The plasma orexin-A levels in patients with COPD group （1.87±0.43）ng/L was higher than those in the control group （1.49±0.19）ng/L, P< 0.01. Plasma orexin-A levels in patients with COPD correlated negatively with FEV1（r=-0.389，P<0.05），and correlated positively with P0.1（r=0.728，P< 0.01）.Conclusions: The plasma orexin A in COPD patients are increased which may be caused by smoking and hypercapnia. Orexin A may play a crucial role in the regulation of respiratory drive in COPD patients.

Key words: pulmonary disease, chronic obstructive, respiratory function tests, respiratory center, orexin-A