天津医药

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肾原发性横纹肌肉瘤二例报告

杨雄1,孙二琳2,杨宇明3,张淑敏3,畅继武1,韩瑞发1   

  1. 1. 天津市泌尿外科研究所
    2. 天津医科大学第二医院 天津市泌尿外科研究所
    3. 天津医科大学第二医院泌尿外科天津市泌尿外科研究所
  • 收稿日期:2010-08-19 修回日期:2010-11-22 出版日期:2011-04-15 发布日期:2011-04-15
  • 通讯作者: 杨雄

Two cases report of primary rhabdomyosarcoma of the kidney and review of the literature

  • Received:2010-08-19 Revised:2010-11-22 Published:2011-04-15 Online:2011-04-15

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摘要： [摘要] 目的 探讨肾原发性横纹肌肉瘤的临床病理学特点。方法 分析2例肾原发性横纹肌肉瘤患者临床资料并文献复习，应用免疫组化SP法检测肾原发性横纹肌肉瘤Vimentin、Myoglobin、Desmin、α-SMA、EMA 、NSE、S-100的表达，结合临床病理特征进行分析。结果 肾原发性横纹肌肉瘤占我院同期肾脏恶性肿瘤的0.2%（2/1081），2例均为男性；左肾1例，右肾1例。组织学上肿瘤组织由交织成束状排列的长梭形细胞组成，胞浆丰富，嗜伊红，核居中，呈长圆形，两端钝。经SP染色后，Vimentin均呈阳性或强阳性表达，而Myoglobin、Desmin均呈阴性表达。 结论 肾原发性横纹肌肉瘤较为罕见，诊断与鉴别诊断取决于病理组织形态学和免疫分子表型特征。

关键词: 肾肿瘤, 横纹肌肉瘤, 病理学, 组织形态学, 免疫组织化学

Abstract: Abstract: Objective To study the clinicopathological features and immunophenotype of primary rhabdomyosarcoma of the kidney. Methods 2 cases of primary rhabdomyosarcoma of the kidney were collected from 2000 to 2009 in the second hospital of Tianjin medical university.The immunohistochemical SP method was used to detect the expression of Vimentin、Myoglobin、Desmin、α-SMA、EMA、NSE、S-100.The clinical findings were analyzed and the hematoxylin and eosin-stained sections were reviewed. Results Primary rhabdomyosarcoma of the kidney account for 0.2% of malignant renal tumors. Both of the patients were male.One tumor was on the left and one on the right.The tumors with moderate pleomorphism composed of alternating fascicles of spindle cells with blunt-ended nuclei and eosinophilic cytoplasm.After SP staining, Vimentin showed positive or strong positive expression, but Myoglobin, Desmin was negative, EMA, NSEand S-100 expression in various degrees. Conclusion Primary leiomyosarcoma of the kidney is a rare malignant tumor of the kidney.Diagnosis of this tumor need to be differentiated from diverse malignant renal tumors by pathohistology、histochemical stain and immunohistochemical stain.

Key words: Kidney neoplasms, rhabdomyosarcoma, Pathology, Histologic appearance, Immunohistochemistry