天津医药

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Notch通路及维甲酸与肾纤维化研究进展

杜轩,涂卫平   

  1. 南昌大学第二附属医院
  • 收稿日期:2013-11-15 修回日期:2014-05-28 出版日期:2014-09-15 发布日期:2014-09-15
  • 通讯作者: 杜轩

Notch Signaling in Renal Interstitial Fibrosis and Retinoic Acid

DU Xuan 1,TU Weiping 2   

  1. 1. Department of Nephrology, the Second Affiliated Hospital oNanchang 330006, Chinaf Medical College of Nanchang University,
    2. Department of Nephrology, the Second Affiliated Hospital of Medical College of Nanchang University，Nanchang 330006, China
  • Received:2013-11-15 Revised:2014-05-28 Published:2014-09-15 Online:2014-09-15
  • Contact: DU Xuan

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摘要： 摘要：维甲酸（retinoic acid,RA）对肾间质纤维化(renal interstitial fibrosis,RIF)存在着重要的影响，Notch信号途径在肾纤维化中发挥了关键作用，本文就维甲酸对肾纤维化与Notch通路的影响做综述，探索维甲酸干预Notch途径能否成为新的抗肾纤维化策略。

关键词: 维甲酸, Notch信号, 肾间质纤维化

Abstract: Abstract:The effect on Renal Interstitial Fibrosis(RIF) by Retinoic Acid(RA) is wide and important. Notch signaling is known to play an important role in the pathology route of RIF. This paper summarizes recent research progress on the effect on RIF and Notch signaling by RA. Interruption of Notch signaling by RA might be a potential anti-fibrotic strategy in RIF.

Key words: retinoic acid, Notch signaling, renal interstitial fibrosis