天津医药

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鞘内注射甲基强的松龙治疗多发性硬化的疗效及住院费用相关分析

董艳玲   

  1. 广西壮族自治区人民医院神经内科
  • 收稿日期:2011-05-30 修回日期:2011-08-30 出版日期:2012-01-15 发布日期:2012-01-15
  • 通讯作者: 董艳玲

Curative effect studies of intrathecal injection methylprednisolone in treatment of multiple sclerosis and the relativity between cost of hospitalization and therapy methods

  • Received:2011-05-30 Revised:2011-08-30 Published:2012-01-15 Online:2012-01-15

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摘要： 摘要：目的 探讨鞘内注射甲基强的松龙治疗急性期多发性硬化（multiple sclerosis,MS）的疗效、与住院费用、住院天数的关系，为临床治疗方案的选择提供参考。方法 将70例MS按主要治疗方法分为鞘内注射甲基强的松龙（MPS）组、MPS冲击组，比较治疗后两组不同时间的Kurtzke扩展致残量表（Kurtzke expanded disability status scale，EDSS）评分减少数，依据治疗方法的不同，对其总住院费用、日均住院费用及药品比例等进行统计学分析。结果 分别应用鞘内注射甲基强的松龙、甲基强的松龙冲击治疗的患者，其5d时扩展致残量表平均改善值分别为（1.088±0.995）分、（0.429±0.763）分；其15d时扩展致残量表平均改善值分别为（1.483±1.332）分和（1.479±1.326）分；平均总住院费用分别为（6520.78±1536.26）元、（11059.01±2356.32）元；日均住院费用分别为（532.22±97.37）元、（664.01±105.68）元；平均住院天数分别为（12.8±2.3）d、（20.7±3.9）d。结论 鞘内注射甲基强的松龙（MPS）组患者神经功能改善优于MPS冲击组，鞘内注射MPS组治疗早期EDSS评分减少较MPS冲击组显著，见效快，总住院费用、日均费用、药品比例低及住院天数短。MPS冲击组住院费用及日均费用高，药品比例高，住院天数长。

关键词: 多发性硬化, 甲基强的松龙（MPS）, 鞘内注射, 住院费用

Abstract: Abstract: Objective To evaluate the relationship in the cost of hospitalization，in hospital day and the effect of Intrathecal injection methylprednisolone for acute multiple sclerosis(MS). Methods 70cases were divided into two groups as intrathecal methylprednisolone group and methylprednisolone impact group，then evaluated the reduction of Kurtzke expanded disability status scale（EDSS）and the rate of side effects at different time after treatment. The average total cost of hospitalization， average cost of hospitalization per day， the proportional of drugs were analysed with the software of SPSS13.0. Results Aerage improvement in mean expanded disability status scale （EDSS）in intrathecal methylprednisolone group ，methylprednisolone impact group and dexamethasone group at 5day were（1.088±0.995）scores and（0.429±0.763）scores ，at 15day were（1.483±1.332）scores and（1.479±1.326）scores，the average costs of hospitalization were （6520.78±1536.26） yuan and （11059.01±2356.32） yuan ， and the average costs of hospitalization per day were （532.22±97.37） yuan and（664.01±105.68） yuan，average hospitalizing days were （12.8±2.3） days and（20.7±3.9） days . Conclusion The improvement of EDSS scale of intrathecal methylprednisolone group were significantily obvious compared with the control group during earlier period of treatment. Intrathecal methylprednisolone therapy worked faster compared with the control group, the average total cost of hospitalization is the and average hospitalizing days is more shorter，the proportional of drugs of intrathecal methylprednisolone group is decrease. The average total cost of hospitalization and average cost of hospitalization per day in methylprednisolone impact group costs are the most ，the proportional of drugs is increase. the average hospitalizing days of methylprednisolone impact group is the longer.

Key words: Multiple sclerosis(MS), Methylprednisolone（MPS）, Intrathecal injection, Cost of hospitalization