天津医药

• 论著 •    

HIF-1α和VEGF-C在前列腺癌中的表达及意义

王晋龙1,白铁男2,胡海龙3,韩瑞发4,赵朋5   

  1. 1. 天津医科大学第二医院 泌尿外科
    2. 天津医科大学第二医院，天津泌尿外科研究所
    3. 天津医科大学第二医院；天津市泌尿外科研究所
    4. 天津市泌尿外科研究所
    5. 天津医科大学第二附属医院
  • 收稿日期:2011-05-13 修回日期:2011-08-08 出版日期:2012-01-15 发布日期:2012-01-15
  • 通讯作者: 王晋龙

Expression and clinical significance of HIF-1α and VEGF-C in Prostate Cancer

  • Received:2011-05-13 Revised:2011-08-08 Published:2012-01-15 Online:2012-01-15
  • Contact: Jin-Long WANG

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摘要： 摘要 目的：探讨缺氧诱导因子-1α( HIF-1α)和血管内皮生长因子C (VEGF-C)在前列腺癌中的表达及其临床意义。方法：应用免疫组织化学SABC法检测59例前列腺癌（PC）组织及13例良性前列腺增生 (BPH) 组织中HIF-1α和VEGF-C表达情况，并分析两者相关性及其表达与临床病理特征的关系。结果：HIF-1α和VEGF-C在PC组中的阳性表达分别为66.1%、76.3%，明显高于BPH组(7.7%和0), 差异有统计学意义(P<0.01)。HIF-1α和VEGF-C阳性表达率在不同肿瘤分化程度、临床分期、有无淋巴结转移的患者间差异有统计学意义(P<0.05)，而与患者不同年龄和PSA值的无关（P>0.05）。在PC中HIF-1α与VEGF-C的表达呈正相关(r =0.261，P < 0.01)。 结论：HIF-1α的过表达可能通过激活下游基因VEGF-C的表达协同参与前列腺癌的发生、发展，促进肿瘤的转移。

关键词: 缺氧诱导因子-1α, 血管内皮生长因子-C, 前列腺癌, 转移, 免疫组化

Abstract: Abstract Objective: To study the different expression and clinical significance of hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth factor C (VEGF-C) in the prostate carcinoma. Methods: SABC immunohistochemical analysis was used to determine the expression levels of HIF-1α and VEGF-C in 59 cases of prostate carcinoma (PC) and 13 cases of benign prostatic hyperplasia (BPH). The expression and relationship of HIF-1α and VEGF-C with clinic-pathological features were analyzed. Results: The expressions of HIF-1α and VEGF-C were significantly higher in PC (66.1%, 76.3% respectively) compared with BPH (7.7%, 0 respectively). The expressions of HIF-1α and VEGF-C in neoplastic tissue of patients were closely correlated with the tumor differentiation, clinical stages and the lymph node metastasis (P<0.05). Their expressions, however, did not show any correlations to the patient’s age and PSA level (P>0.05). There was a positive correlation between the expressions of HIF-1α and VEGF-C in prostatic carcinoma(r=0.261, P<0.05). Conclusion：The synergy of HIF-1α and VEGF-C may play a great role in the genesis and development of prostate tumor. Maybe the over-expression of HIF-1αinduces tumor invasion by activating the transcription of VEGF-C.

Key words: hypoxia-inducible factor 1 α, vascular endothelial growth factor C, prostate carcinoma, metastasis, immunohistochemistry