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肾结石患者血清尿激酶水平及其与钙离子的相关性

明星,辛文虎,岳中瑾   

  1. 兰州大学第二附属医院
  • 收稿日期:2013-06-13 修回日期:2013-09-02 出版日期:2013-12-15 发布日期:2013-12-15
  • 通讯作者: 岳中瑾

Urokinase level in Serum and Its Relationship with Calcium in Kidney Stone Patients

  • Received:2013-06-13 Revised:2013-09-02 Published:2013-12-15 Online:2013-12-15

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摘要：

【摘要】 目的   观察肾结石患者血清尿激酶（UK）和钙离子水平的变化及二者的相关性，探讨UK在肾结石形成中的作用。  方法  选取肾结石患者27例（结石组）和健康体检者24例（对照组），应用双抗体夹心酶联免疫吸附试验(ELISA)法检测2组血清UK水平，自动生化分析仪检测血清钙离子水平和肌酐水平。   结果     结石组血清UK（μg/L：0.49±0.15vs1.44±0.55）低于对照组、钙离子（mmol/L2.30±0.18vs2.18±0.13）高于对照组，肌酐浓度[μmol/L：93.62（54.38,126.26）vs58.34（46.53,83.24）]高于对照组（均P＜0.05）。结石组UK水平与钙、肌酐均呈负相关（r及rs分别
为-0.741、-0.459，均P＜0.05）。  结论    UK有望成为一种新型结石形成的抑制剂，通过保护肾功能降低钙离子水平而抑制结石的形成。

关键词: 肾结石, 尿激酶, 钙离子, 肌酐

Abstract: objective To observe serum urokinase level and calcium in kidney stone patients and analysis the relevance. Methods 27 patients with calculus (stone group) and 24 healthy crowd (control group) were divided into two groups, serum urokinase level of all research object were measured by enzyme-linked immuno sorbent assay(ELISA), serum calcium level was test by biochemical detection, at the same time test renal function (serum creatinine). Results The serum urokinase level with stone group was lower than control group (P < 0.001), calcium level was higher than control group (P < 0.01); The change of of urokinase level and calcium level of stone group was negatively correlated(P < 0.01), the change of urokinase and creatinine level was negatively correlated too(P < 0.05). Conclusion The Serum urokinase level of healthy crowd was higher than patients with stone, and the urokinase may be as a new inhibitor restrain the process of stone formation by protecting renal function and reducing calcium levels.