天津医药

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EBP50、AKT2在乳腺癌中的表达及意义

时志民   

  1. 河北工程大学丛台校区医学院病理
  • 收稿日期:2010-01-26 修回日期:2010-03-03 出版日期:2010-09-15 发布日期:2010-09-15
  • 通讯作者: 时志民

The expression of EBP50、AKT2 in human breast cancer tissue and its significance

shi zhimin   

  • Received:2010-01-26 Revised:2010-03-03 Published:2010-09-15 Online:2010-09-15
  • Contact: shi zhimin

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摘要： 摘要：目的 研究乳腺癌组织中EBP50、AKT2蛋白的表达与临床病理指标的关系及其预后意义。方法 应用免疫组化SP法，检测56例乳腺癌组织、30例癌旁正常乳腺组织石蜡切片中EBP50、AKT2的表达，并分析两种蛋白分子的表达与临床病理学指标之间的关系。结果 ①56例乳腺癌组织中EBP50和AKT2的表达率分别为30.36%、76.79%，与正常乳腺组织相比有显著性差异( P<0.05)。②EBP50的表达与乳腺癌的组织学分级、临床TNM分期和淋巴结转移有关( P<0.05),而与患者年龄大小、原发肿瘤大小无关( P<0.05)。AKT2的表达与乳腺癌的淋巴结转移有关(P<0.05)，与乳腺癌的原发肿瘤大小、组织学分级、临床TNM分期以及患者年龄大小无关(P>0.05)的表达。③在乳腺癌中EBP50与与核表达AKT2呈显著负相关( P<0.05)。结论 EBP50、AKT2的异常表达与乳腺癌的发生、发展及浸润转移有关，可作为判断乳腺癌生物学行为和预后的重要指标。

关键词: 乳腺肿瘤, EBP50, AKT2, 免疫组织化学

Abstract: Abstract:Objective　To investigate the expression of EBP50、AKT2in human breast cancer tissue, study their relationship with clinicopathological factor in breast cancer, and analyze their expression significance and their correlation with each other.Methods　The expression of EBP50、AKT2 in 56 cases of breast carcinoma and 30 cases of adjacent nontumor normal breast tissue was detected by SP immunohistochemistry. Results　①The postitive expression of EBP50、AKT2 in 56 cases of breast carcinoma were 30.36% and 76.79% respectively.There was a significant different between carcinoma and normal breast tissue(P< 0.05);②The overexpression of EBP50 in breast carcinoma had no relationship with the size of primary tumor, age and pathological type, but had some relationship with histological classification, clinical TNM staging, and lymph node metastasis (P<0.05); AKT2 expression was inversely correlated with lymph node metastasis (P<0.05), had no relationship with age, size of primary tumor, histological classification, clinical TNM staging and pathological type (P>0.05).③EBP50、AKT2 showed significant indirect correlation with each other invasive ductal carcinoma. Conclusion The overexpression of EBP50、AKT2 may play a important role in the carcinogenesis and progression of breast carcinoma. They may be as the indications of biological behavior and prognosis of breast carcinoma.

Key words: breast tumor, EBP50, AKT2, immunohistochemistry