天津医药

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胸腺素β10在食管癌中表达的病理意义

刘尚国1,李汉臣2,赵宝生2,王忠民2,秦秀广2,齐 博2   

  1. 1. 新乡医学院第一附属医院
    2.
  • 收稿日期:2009-11-18 修回日期:2010-01-15 出版日期:2010-09-15 发布日期:2010-09-15
  • 通讯作者: 刘尚国

Clinicopathologic significance of the expression of thymosinβ10 protein in human esophageal carcinoma

  • Received:2009-11-18 Revised:2010-01-15 Published:2010-09-15 Online:2010-09-15

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摘要： 摘要 目的： 胸腺素最早是从牛胸腺中提取出来的，后来发现它普遍存在于多种肿瘤组织中。本研究旨在探讨胸腺素β10(Thymosinβ10，Tβ10)在人类食管癌中表达的临床病理意义。方法： 应用免疫组织化学法检测胸腺素β10在70例食管癌和30例癌旁正常食管黏膜中的表达，将检测结果与常见临床病理参数间的关系进行统计学分析。结果： 胸腺素β10主要表达在癌细胞胞浆中。食管癌中的阳性率75.71%（53/70）显著高于癌旁正常食管黏膜中的阳性率23.33%(7/30) (P<0.01)。高分化食管癌中的阳性率低于中、低分化癌中的阳性率，粘膜或粘膜下层食管癌中的阳性率低于肌层以上癌中的阳性率，无淋巴结转移食管癌中的阳性率低于有淋巴结转移癌中的阳性率 (P均<0.05)，与患者的性别、年龄、肿瘤的部位、大小无显著相关（P>0.05）。结论：　胸腺素β10的在食管癌中高表达，与食管癌的分化、浸润和转移有关，可能成为人类食管癌诊断的一种新的肿瘤标志物。

关键词: 食管癌, 胸腺素β10

Abstract: ABSTRACT　AIM: The thymosin originally isolated from calf thymus, recently, it has been demonstrated overexpression in various neoplastic tissues. This study was to investigate the clinicopathologic significance of the expressions of thymosinβ10 in human esophageal carcinoma. METHODS: Immunohistochemical（IHC）staining was used to detect the expression of thymosinβ10 in 70 cases of esophageal carcinoma and 30 cases of para-cancerous normal esophageal mucosa, the results in combination with common clinicopathological parameters were statisticly analyzed. RESULTS: Thymosinβ10 expressed in the cytoplasm. The positive expression rate of thymosinβ10 in esophageal carcinoma 75.71%（53/70） was much higher than that in para-cancerous normal esophageal mucosa 23.33%(7/30) (P<0.01). The positive expression rate of thymosinβ10 in well differential esophageal carcinoma was much lower than that in moderate or poor carcinoma, the positive expression rate of thymosinβ10 in esophageal carcinom of mucosa or submucosa was much lower than that in muscularis propria carcinoma，the positive expression rate of thymosinβ10 in esophageal carcinom of negative lymph node metastasis was much lower than that in positive lymph node metastasis (allP<0.05). Thymosinβ10 expression had no relation with sex, age, site and size（P>0.05）. CONCLUSION: Thymosinβ10 was highly expressed in esophageal carcinoma, it was correlated with the differentiation, invasion and metastasis of esophageal carcinoma, it might be a new tumor marker for diagnosing of the human esophageal carcinoma.

Key words: Esophageal carcinoma, Thymosinβ10