B7-CD28/CTLA4共刺激途径在再生障碍性贫血免疫机制中作用

• 综述与讲座 •

B7-CD28/CTLA4共刺激途径在再生障碍性贫血免疫机制中作用

高丽娜¹,刘宝山²,杨文华。³

1. 天津中医药大学第一附属医院
2.
3. 天津中医一附院血液科

收稿日期:2009-09-24 修回日期:2010-01-10 出版日期:2010-06-15 发布日期:2010-06-15
通讯作者: 高丽娜

B7-CD28/CTLA4 stimulates approach together middle acting on immune mechanism of aplastic anemia

Received:2009-09-24 Revised:2010-01-10 Published:2010-06-15 Online:2010-06-15

高丽娜1 ,刘宝山2 ,杨文华。3 . B7-CD28/CTLA4共刺激途径在再生障碍性贫血免疫机制中作用[J]. .

摘要/Abstract

摘要： 　T淋巴细胞是细胞免疫反应中的主要效应细胞，细胞免疫应答的中心环节是T细胞对抗原的识别和有效激活，即T细胞激活的的双信号机制，其中TCR与MHC-Ag复合物的结合为第一信号；递呈细胞(APC)提供的协同刺激信号为第二信号。T细胞上的CD28/ CTLA4与抗原递呈细胞上的B7分子[B7-1(CD80)，B7-2(CD86)]是目前发现的最为重要的协同刺激分子，它们在自身免疫病患者T细胞及抗原递呈细胞上有异常表达，且参与致病过程。这些分子及其同系物与受体结合后，在T细胞免疫应答的不同阶段中起着重要的调节作用，涉及整个免疫系统中细胞免疫和体液免疫正向负向调节的诸多方面。正确理解这些通路将为自身免疫性疾病的治疗提供新的前景。

关键词: B7-CD28/CTLA4, 共刺激信号, 再生障碍性贫血

Abstract: T lymphocytes are the major effect of the cellular immune response cells. The Central link of the immune response is the recognition of t-cell activation antigen and effective, activate t-cells have double signal mechanism, including TCR with MHC Ag - for the first signal of the complex, APC provides for the second signal collaborative stimulate signal.CD28/ CTLA4 and B7 B7 [B7-1(CD80)，B7-2(CD86)] are currently the most important discovery in collaborative stimulation, they not only have abnormal effect on T cell and the antigen of autoimmunity disease patient,but also participate in pathopoiesia process. After These molecules and their surname combing with the acceptor, in different stages of T cells immune response wich plays an important role in regulating, involving the immune system cells and humoral immune regulation of positive negative aspects. Correct understanding of these pathways for autoimmune diseases will provide a new prospect of treatment.

Key words: B7-CD28/CTLA4, Stimulation of signal, Aplastic anemia