天津医药

• 综述与讲座 • 上一篇    

唑类抗真菌药物与尖端扭转型室性心动过速

孔祥君,聂振华   

  1. 天津市长征医院
  • 收稿日期:2010-10-25 修回日期:2011-03-17 出版日期:2011-10-15 发布日期:2011-10-15
  • 通讯作者: 孔祥君

Azole Antifungal agents with Torsades de pointes

adcc102 ,Zhen-Hua NIE   

  • Received:2010-10-25 Revised:2011-03-17 Published:2011-10-15 Online:2011-10-15
  • Contact: adcc102

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摘要： [摘要]尖端扭转型室性心动过速（TdP）是一种恶性心律失常,临床多继发于某些药物的使用。近年来研究显示，抗真菌药物是重要的可诱发尖端扭转型室性心动过速的药物之一。其机制包括与心肌细胞hERG钾通道作用影响心肌复极，以及与细胞色素P450作用影响药物代谢等。并与个体因素密切相关。

关键词: 抗真菌药物, 尖端扭转型室性心动过速, hERG, 细胞色素P450, 长QT间期综合征

Abstract: [Abstract] Torsades de pointes (TdP) is a malignant arrhythmia, mostly secondary to the use of certain drugs. Recent studies have suggested that it is important antifungal agents can induce TdP. The mechanism including the inhibition of myocardial hERG potassium channel of cardiac repolarization, as well as the inhibition of cytochrome P450 and so on. It also closely related with the individual factors.

Key words: Antifungal Agents, Torsades de pointes, hERG, CYP, LQTS