妊娠期糖尿病患者脂代谢异常对新生儿出生体质量的影响

妊娠期糖尿病患者脂代谢异常对新生儿出生体质量的影响

匡德凤

天津市河西区平江道23号天津医科大学第二医院

收稿日期:2011-12-05 修回日期:2012-06-25 出版日期:2012-11-15 发布日期:2012-11-15
通讯作者: 匡德凤

Relationship Between Blood lipids levels and weight of newborns in pregnant women with Gestational Diabetes Mellitus

Received:2011-12-05 Revised:2012-06-25 Published:2012-11-15 Online:2012-11-15

匡德凤. 妊娠期糖尿病患者脂代谢异常对新生儿出生体质量的影响[J]. .

摘要/Abstract

摘要： 目的：研究妊娠期糖尿病（GDM）患者脂代谢异常对新生儿出生体质量的影响，为合理管理妊娠期糖尿病孕妇提供临床参考。方法：106例妊娠女性分为妊娠期糖尿病（GDM组，n=50）组、妊娠期糖耐量受损（GIGT组，n=24）组及糖耐量正常（NGT组，n=32）。比较3组孕妇血脂水平、孕期体质量增加及围产资料。结果：GDM组总胆固醇（TC）及三酰甘油（TG）水平均高于GIGT和NGT组，差异有统计学意义（P <0.05）。3组孕妇分娩前体质量差异有统计意义（P＜0.01），且GDM组明显高于其他2组。GDM组新生儿出生体质量、孕妇术中羊水粪染及新生儿转入重症监护病房(NICU)的几率高于其他2组，差异有统计学意义（P＜0.05）；GDM组孕妇血糖、TG水平及孕妇孕期体质量增加与新生儿出生体质量间存在正相关（ｒ值分别为0.528、0.632、0.585，P＜0.05）。结论：在控制血糖的基础上，积极控制血脂水平，将减少胎儿体重增加过多、甚至巨大儿的发生，从而降低围产期并发症，保障母婴安全。

关键词: 妊娠期糖尿病、血脂、新生儿出生体质量

Abstract: Objective:To study the influences of blood lipid levels in gestational diabetes mellitus ( GDM ) patients to neonatal birth weight and Provide clinical reference for reasonable management of pregnant women with gestational diabetes mellitus Methods: 106 cases of pregnant women according to the American Diabetes Association (ADA) standards were divided into gestational diabetes (GDM, n = 50) group, gestational impaired glucose tolerance (GIGT, n = 24) group and normal glucose tolerance (NGT, n = 32) 3 groups. Recorded the group of pregnant women lipid levels, weight gain during pregnancy and the group of perinatal data. Results: TC and TG levels on GDM group were higher than the GIGT and the NGT group, the difference was statistically significant (P <0.01). The average weight of pregnant women of three groups before delivery was different, that in GDM group were higher than other two groups. Compared with the other two groups, neonatal birth weight, meconium-stained and the probability into the intensive care room in GDM group were significantly higher than the other two groups, the difference was statistically significant; TG level and growth of body mass during pregnancy were significantly positive correlated to neonatal body weight.( r=0.528,0.632,0.585，P <0.05). Conclusion: Controling lipids level positively on the basis of control blood glucose will reducte fast growth of neonatal body weight、even the happen of macrosomia , thus reduce risk of perinatal complications, ensure safe motherhood.

Key words: gestational diabetes, blood lipids, weight of newborns