天津医药

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血府逐瘀胶囊治疗恶性肿瘤高凝状态的临床观察

蔡玉梅,牛雪娇,崔宇,吴晓静,庞雁,姚嫱   

  1. 天津市人民医院
  • 收稿日期:2012-12-18 修回日期:2013-04-19 出版日期:2014-01-15 发布日期:2014-01-15
  • 通讯作者: 姚嫱

Clinical Effects of Chinese medicine-xufuzhuyu capsule on the hyper-coagulation state of cancer

  • Received:2012-12-18 Revised:2013-04-19 Published:2014-01-15 Online:2014-01-15

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摘要： 目的 探讨血府逐瘀胶囊治疗恶性肿瘤高凝状态的临床效果。方法 将72例存在高凝状态的恶性肿瘤患者随机分为治疗组和对照组， 每组36例。治疗组在对症支持治疗的基础上口服血府逐瘀胶囊， 每日2次， 每次6粒 （2.4 g）， 28 d为1个疗程； 对照组单纯对症支持治疗。检测治疗前后外周血活化部分凝血酶时间 （APTT）、 凝血酶原时间 （PT）、 纤维蛋白原 （FIB）、 D-二聚体水平及血小板计数 （PLT）。结果 治疗后治疗组FIB、 D-二聚体和PLT降低，对照组D-二聚体升高， 治疗组FIB和D-二聚体均较对照组降低 （P＜0.05或P＜0.01）， 治疗组有效15例 （41.7%）， 对照组有效3例 （8.3%）， 2组有效率比较差异有统计学意义 （χ2=10.667， P＜0.05）。结论 血府逐瘀胶囊可以明显改善恶性肿瘤患者的高凝状态。

关键词: 恶性肿瘤, 高凝血症, 血府逐瘀胶囊

Abstract: Objective: To investigate the clinical effection of xufuzhuyu capsule on the hyper-coagulation state of cancer. Methods: A total of 72 cancer patients with histological diagnoses, which serological examinations showed hypercoagulable state were included in the study. The patients were randomly divided into treatment group and control group, 36 cases for each. Patients received 2.4g xufuzhuyu capsule twice a day for 28 days in treatment group, and received symptomatic and supportive treatment alone in control group. The peripheral blood APTT, PT, FIB, D-dimer levels and platelet counts were detected within a week before and after treatment Results: The peripheral blood FIB, D-dimer levels and platelet counts in treatment group were lower than that in control group (P <0.05) after treatment, and the peripheral blood D-dimer levels after treatment were higher than that befoer treatment in control group. The effective rate in treatment group was 41.7%, which was significantly higher than 8.3% in control group (P<0.05). Conclusion: Xufuzhuyu capsule can significantly improve hyper-coagulation state in cancer patients. Study more in detail on the field is of important value to guide clinical practice and drug development work.

Key words: cancer, hyper-coagulation, Xufuzhuyu capsule