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阿托伐他汀治疗对不稳定型心绞痛患者高敏C反应蛋白和基质金属蛋白酶-9的影响

魏嵩昀   

  1. 天津市职业病防治院（工人医院）
  • 收稿日期:2012-04-16 修回日期:2012-08-02 出版日期:2013-01-15 发布日期:2013-01-15
  • 通讯作者: 魏嵩昀

Effect of high sensitivity C reactive protein and matrix metalloproteinase 9 on the patients with unstable angina pectoris treated with Atorvastatin

  • Received:2012-04-16 Revised:2012-08-02 Published:2013-01-15 Online:2013-01-15

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摘要：

【摘要】 目的研究应用阿托伐他汀对不稳定型心绞痛(UA)患者血清高敏C反应蛋白(hsCRP)和基质金属蛋白酶(MMP)-9的影响。方法将106例UA患者随机分为2组,治疗组50例,对照组56例。对照组仅给予常规治疗,治疗组在常规治疗基础上加服阿托伐他汀40mg/d,共30d,分别检测2组患者治疗前后的血清hsCRP和MMP-9水平。结果治疗组与对照组治疗前TC、TG、LDL-C和HDL-C差异无统计学意义。治疗组治疗后TC、LDL-C水平明显降低,HDL-C水平明显上升,差异有统计学意义(P<0.01)。治疗组与对照组治疗前hsCRP和MMP-9差异无统计学意义。治疗组治疗后hsCRP和MMP-9水平较治疗前明显降低,差异有统计学意义(均P<0.01)。结论阿托伐他汀除调脂作用外,还有抗炎、稳定斑块及防止斑块破裂的作用。 

关键词: 阿托伐他汀, 不稳定型心绞痛, 血清高敏C反应蛋白, 基质金属蛋白酶-9

Abstract: [Abstract] Objective:To investigate the effect of high sensitivity C reactive protein(hsCRP) and matrix metalloproteinase 9(MMP-9) on the patients with unstable angina pectoris treated with Atorvastatin. Methods:106 patients with UA were divided into 2 groups,50 patients in the treatment group were treated with Atorvastatin 40mg every day for therthy days,in addition to the conventional therapy. 56 patients in the control group were treated with the conventional therapy.The detection was performed to test the hsCRP and MMP-9 in two groups.Results:① Two groups before treatment do not have difference on total cholesterol(TC),low density lipoprotein- cholesterol(LDL-C),high density lipoprotein- cholesterol(HDL-C).② The treatment group after treatment have a significant difference on TC，LDL-C，HDL-C（P<0.05）.③ To compare 2 groups before treatment and the control group after treatment, hsCRP and MMP-9 have no difference.④ HsCRP and MMP-9 in the treatment group after treatment decreased significantly（P<0.05，P<0.01）.Conclusion: HsCRP and MMP-9 in patients with unstable angina pectoris treated with Atorvastatin have a significant decrease.The data suggested that Atorvastatin can inhibite inflammation,stable plaque and prevent fracture of plaque in addition to regulate lipid.

Key words: Atorvastatin, unstable angina pectoris, high sensitivity C reactive protein, matrix metalloproteinase 9