天津医药

• 论著 •    

Livin和Caspase-3在喉鳞癌组织中表达的意义及相关性分析

徐勤,高珊   

  1. 河北省承德医学院附属医院
  • 收稿日期:2012-02-03 修回日期:2012-08-24 出版日期:2012-12-15 发布日期:2012-12-15
  • 通讯作者: 徐勤

The Expression of Livin and Caspase-3 in Laryngeal squamous cell Carcinoma and the correlation between Livin and Caspase-3

  • Received:2012-02-03 Revised:2012-08-24 Published:2012-12-15 Online:2012-12-15

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摘要： 目的：研究Livin和Caspase-3这两种蛋白在喉鳞癌组织中表达的意义及相关性分析。方法：免疫组化SP法检测Livin和Caspase-3蛋白在30例声带息肉和62例喉鳞癌中的表达情况。结果：Livin在喉鳞癌组织中表达显著高于声带息肉组织(P＜0.01)，而Caspase-3在声带息肉组织中的表达显著高于喉鳞癌组织(P＜0.05)；Livin和Caspase-3的表达与喉鳞癌的淋巴结转移、临床分期、组织分化程度均显著相关 (P＜0.05)，而与喉鳞癌的临床分型、吸烟史、年龄、性别无关(P＞0.05)；Livin与Caspase-3在喉癌组织中表达呈显著负相关(r=-0.448, P＜0.05)。结论：Livin和Caspase-3关系密切，二者异常表达可能在喉鳞癌的发生发展及转移中发挥重要作用。

关键词: Livin, Caspase-3, 喉鳞癌, 免疫组化SP法

Abstract: PURPOSE: TO investigate the expression and their significance in laryngeal squamous cell carcinoma and the correlation between livin and Caspase-3. METHODS: Immunohistochemistry was used to detect the expression of livin and caspase-3 in 30 cases of polyp of vocal cord and 62 cases of laryngeal squamous cell carcinoma. RESULTS: The expression of livin laryngeal squamous cell carcinoma was significantly higher than that in polyp of vocal cord(P＜0.01), however the expression of Caspase-3 was significantly higher in polyp of vocal cord than that in laryngeal squamous cell carcinoma (P＜0.01). In laryngeal carcinoma,the expression of livin and Caspase-3 were associated with patients′Lymph node metastasis, Clinical stage and Differentiation (P＜0.05), but independent of Clinical classification ,smoking history,patients′age and sex(P＞0.05). A signifcantly negative relation was found between livin and Caspase-3 (P＜0.05). CONCLUSION: Livin was positively related to Caspase-3,which might play an important role in the carcinogenesis and development of laryngeal carcinoma by synergic effect.

Key words: Livin, Caspase-3, Laryngeal squamous cell Carcinoma, Immunohistochemistry