天津医药

• 论著 •    

非痴呆性血管性认知功能障碍相关因素分析

高薇薇1,薛蓉2,程炎2   

  1. 1. 天津市医科大学总医院神经内科
    2. 天津医科大学总医院神经内科
  • 收稿日期:2009-11-05 修回日期:2009-11-09 出版日期:2010-06-15 发布日期:2010-06-15
  • 通讯作者: 高薇薇

The relationship and analysis with vascular cognitive impairment not dementia and risk factors

  • Received:2009-11-05 Revised:2009-11-09 Published:2010-06-15 Online:2010-06-15

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摘要： 目的：探讨非痴呆性血管性认知功能障碍（Vascular Cognitive Impairment Not Dementia,VCIND）与相关危险因素的关系，促进对非痴呆性血管性认知功能障碍的早期识别，早期诊断及防治。方法：收集于2009年4月至2009年8月于我院病房及门诊收治的有缺血性脑血管病危险因素的患者，分为VCIND组35例，认知功能正常组33例，完善相关生化及影像学检查，分析比较两组临床资料。结果：糖尿病、高胆固醇血症、高甘油三酯血症、高同型半胱氨酸血症、颅内外动脉狭窄、脑白质稀疏症在两组间的发生率的比较P均<0.05，差异存在统计学意义，单一危险因素组分别与其各自对照组进行蒙特利尔认知功能评分（Montreal Cognitive Assessment, MoCA）比较，P均<0.05，差异存在统计学意义，依据ESSEN卒中风险评分分成的高、低危组之间的MoCA评分比较，P<0.05，差异具有统计学意义。结论：糖尿病、高胆固醇血症、高甘油三酯血症、高同型半胱氨酸血症、颅内外动脉狭窄及脑白质稀疏症的发生与VCIND发生明显相关，单因素高血压、糖尿病、高胆固醇血症、高甘油三酯血症、高同型半胱氨酸血症发生均可造成认知功能减退，多重危险因素的高危人群认知受损更严重。

关键词: 非痴呆血管性认知功能障碍, 血管性痴呆, 血管性认知功能障碍

Abstract: Objective: To investigate the relationship between the vascular impairment not dementia and the risk factors, this will facilitate the diagnosis and therapy as earlier as possible. Methods: Collect the patients who have the risk factor of ischemic cerebrovascular disease from the ward or the clinic in Tianjin general hospital from April 2009 till August 2009.The patients were divided to 2 groups. The 2 groups are VCIND group and the control group. All the patients have been detected the blood pressure and completed some related chemical and image examinations. Then compare the clinical data between the 2 groups. Result: There are variations in statistics between these two groups in the comparison of rations of diabetes mellitus, hypercholesteremia, hypertriglyceridemia, hyperhomocytinemia, major artery stenosis and white matter lesion. There is also variation in statistics of the score of MoCA between single risk factor group and the control group respectively. We divided all the patient into high risk group and low risk factor group by the score of ESSEN, we can find the variation in statistics by the comparison of MoCA between this 2 group. Conclusion: There are apparent correlation between these risk factors (except hypertension) and VCIND. Any single factor can lead to VCIND. The cognition will be damaged much more severely if the risk factors is more.

Key words: Vascular Cognitive Impairment Not Dementia, Vascular Dementia, Vascular Cognitive Impairment