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急性中心性浆液性脉络膜视网膜病变黄斑区形态学改变与视功能的关系

路露1,徐延山1,李岩1,2,亢雷1,2,谢士勇1,2   

  1. 1. 天津市眼科医院
    2.
  • 收稿日期:2011-01-10 修回日期:2011-01-28 出版日期:2011-05-15 发布日期:2011-05-15
  • 通讯作者: 徐延山

Correlation between morphological and functional changes of macular in acute central serous chorioretinopathy

  • Received:2011-01-10 Revised:2011-01-28 Published:2011-05-15 Online:2011-05-15

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摘要： 摘要 目的：探讨急性中心性浆液性脉络膜视网膜病变（CSC）的形态学改变与视功能变化的相关性。方法：选取急性CSC患者36例（36只眼）应用光学相干断层扫描（OCT）和多焦视网膜电图（mfERG）检测黄斑区形态学改变与视功能变化，探讨急性CSC的黄斑区形态学改变与视功能变化的相关性。结果：急性CSC患者黄斑区神经上皮层脱离高度与最佳矫正视力（BCVA）呈负相关（r=-0.922, P=0.000），神经上皮层脱离水平范围与BCVA成负相关（r=-0.896, P=0.000），黄斑体积与BCVA无相关（r=0.014, P=0.935）。急性CSC患者的mfERGP1波1~3环，N1波2环的潜伏期与BCVA呈负相关（rs=-0.488, P=0.003; rs=-0.514, P=0.001; rs=-0.452, P=0.006; rs=-0.445, P=0.007） N1波1、2环的反应密度与BCVA呈负相关（rs=-0.497, P=0.002; rs=-0.502, P=0.002），N1波2环、P1波1环的潜伏期与神经上皮层脱离高度呈正相关（rs=0.486, P=0.003; rs=0.421, P=0.011）。结论：OCT和mfERG联合应用可准确检测CSC患者的黄斑区形态和功能的变化，CSC患者神经上皮层脱离的高度与黄斑区功能的变化关系密切。

关键词: 中心性浆液性脉络膜视网膜病变, 多焦视网膜电图, 光学相干断层扫描

Abstract: Abstract Objective: To evaluate the correlation between macular morphology and functional in patients with acute central serous chorioretinopathy (CSC). Methods: Thirty-six patients (36 eyes) with acute CSC underwent OCT and mfERG examinations. Macular morphology and its correlation with macular function in patients with acute CSC were explored. Results: There was negative correlation between height, ranges of detachment in macular areas and the best visual acuity (BCVA) (r=-0.922, P=0.000; r=-0.896, P=0.000). But no correlation between macular volume and BCVA (r=0.014, P=0.935). There was significantly negative correlation between BCVA and mfERG P1 latencies of ring 1~3, N1 latency of ring 2(rs=-0.488, P=0.003; rs=-0.514, P=0.001; rs=-0.452, P=0.006; rs=-0.445, P=0.007). There was negative correlation between BCVA and mfERG N1 amplitude density of rings 1, 2(rs=-0.497, P=0.002; rs=-0.502, P=0.002). There was negative correlation between height of detachment in macular area and P1 latency of ring 1, N1 latency of ring 2(rs =0.486，P=0.003; rs=0.421, P=0.011). Conclusions: Combined mfERG and OCT can accurately detect the macular morphology and function in acute central serous chorioretinopathy. There was a close relationship between height of detachment in macular area and macular function.

Key words: central serous chorioretinopathy, multifocal electroretinography, optical coherence tomography