• 临床研究 • 上一篇    下一篇

sTn在子宫内膜癌组织中的表达及临床意义

郭琦,陈秀芹,郭尚云,付建红,翟旭华,杨晓辉,孟芳   

  1. 郑州大学第五附属医院
  • 收稿日期:2013-09-09 修回日期:2014-02-11 出版日期:2014-06-15 发布日期:2014-06-15
  • 通讯作者: 陈秀芹

The expression and clinical significance of sTn in endometrial carcinoma

  • Received:2013-09-09 Revised:2014-02-11 Published:2014-06-15 Online:2014-06-15

摘要: 目的:研究肿瘤相关糖抗原sTn在子宫内膜癌、子宫内膜非典型增生、良性子宫病变患者子宫内膜组织中的表达情况,分析其与子宫内膜癌患者手术病理分期、病理分级等的关系及临床意义。方法: 采用免疫组化方法检测sTn在60例子宫内膜癌、50例子宫内膜非典型增生、50例子宫良性病变患者子宫内膜组织中的表达。结果: sTn在子宫内膜癌、子宫内膜非典型增生、良性子宫病变患者子宫内膜组织中的阳性率分别为71.7%、32%、14%,且相互间具有显著性差异(p<0.05);sTn在子宫内膜样癌组织中表达率为78%,明显高于在良性子宫病变、子宫内膜非典型增生、子宫内膜浆液性囊腺癌患者子宫内膜组织中的表达(p<0.05);sTn在低分化的子宫内膜癌中的表达率显著高于高分化的子宫内膜癌(P<0.05 )。结论: sTn参与了子宫内膜癌的发生发展,在临床上有利于区分癌前病变和癌症,可以作为子宫内膜癌组织学诊断的一个辅助分子,具有重要的临床价值。

关键词: 子宫内膜癌, 肿瘤标记物, sTn

Abstract: Object To investigate the expression and clinical significance of tumor-associated carbohydrate antigen sTn in endometrium from patients with atypical hyperplasia of endometrium , endometrial carcinoma and benign diseases of the uterine. Also analyze the association between sTn and the pathologic stage , pathological grading of endometrial carcinoma. Methods 160 cases were detected by immunohistochemistry, including 60 subjuects with endometrial cancer, 50 subjuects with atypical hyperplasia of endometrium, and 50 subjuects with benign uterine lesions. Results The positive rate of sTn in atypical hyperplasia of endometrium and endometrial carcinoma and benign diseases of the uterine were71.7%、32%、14%, it’s significantly different from each other ( p<0.05 ) . Patietns with endometrioid carcinoma got sTn positvie in 78% among them, significantly higher than that in patients with benign uterine lesions, atypical hyperplasia of endometrium, endometrial serous cystadenocarcinoma (all p<0.05 ).The positive rate of sTn in patietns with poorly differentiated endometrial carcinoma was significantly higher than that in patients with highly differentiated endometrial carcinoma ( P<0.05 ). Conclusion: sTn may play a role in the tumorigenesis and development of endometrial carcinoma, it should be taken as an potential biomarker for endometrial carcinoma.

Key words: endometrial carcinoma, tumor marker, sTn