天津医药

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CDKAL1基因rs7756992位点多态性与2型糖尿病关系的Meta分析

花巍1,尹立群1,步怀恩2,靳英辉1,王泓午1,窦昊颖1   

  1. 1. 天津中医药大学
    2. 天津中医药大学公共卫生教研室
  • 收稿日期:2012-05-09 修回日期:2012-07-12 出版日期:2013-03-15 发布日期:2013-03-15
  • 通讯作者: 花巍

A Meta-analysis on Association of CDKAL1 Gene rs7756992 Polymorphism with Type 2 Diabetes

  • Received:2012-05-09 Revised:2012-07-12 Published:2013-03-15 Online:2013-03-15
  • Contact: Wei HUA

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摘要：

【摘要】目的 评价细胞周期素依赖性激酶5调节亚单位相关蛋白1类似物1（CDKAL1）基因rs7756992位点多态性与2型糖尿病（T2DM）的关系。方法 检索国内外有关CDKAL1基因rs7756992与T2DM关系的随机对照研究文献，提取相关数据并应用RevMan 5.0软件进行Meta分析。结果 共纳入11篇文献，包括T2DM组32 604例，对照组 23 939例。Meta分析结果显示，等位基因及隐性遗传模式下合并OR（95%CI）分别为1.18（1.13，1.23）和1.34（1.25， 1.44）。亚组分析结果显示，CDKAL1基因rs775699位点多态性与亚洲和欧洲人群T2DM发病均存在关联。结论 在在等位基因比较及隐性遗传模式下，CDKAL1 基因rs7756992位点G等位基因突变均为亚洲和欧洲人群T2DM的危险因素。

关键词: 糖尿病, 2型, Meta分析, CDKAL1基因, rs7756992, 多态性

Abstract:

[Abstract] Objective  To evaluate the association of cyclin-dependent kinase 5 regulatory subunit-associated protein 1-like 1 (CDKAL1) gene rs7756992 polymorphism and type 2 diabetes mellitus (T2DM). Methods The case-control studies of CDKAL1 rs7756992 polymorphism and T2DM were collected and meta-analysis was performed by RevMan 5.0 software. Results A total of 11 documents concerning 32 604 diabetics and 23 939 controls were included in this study. The summaryORs（with 95%CI）under allele contrast and recessive model were 1.18 (1.13, 1.23) and 1.34 (1.25, 1.44) , respectively. Subgroup analysis showed the correlation between the CDKAL1 gene rs7756992 polymorphism and incidence of T2DM in European and Asian populations. Conclusion In Asian and European populations，the allele G is the risk factor to T2DM under the two heredity models.

Key words: diabetes mellitus, type 2, meta-analysis, CDKAL1 gen, rs7756992, polymorphism