天津医药

• 药物临床观察 •    

鞘内注射咪唑安定对妇科手术蛛网膜下腔麻醉效果的影响

李肇端1,周汾1,余剑波2   

  1. 1. 天津市南开区三纬路122号南开医院麻醉科
    2. 天津市南开医院
  • 收稿日期:2011-12-07 修回日期:2012-04-07 出版日期:2012-12-15 发布日期:2012-12-15
  • 通讯作者: 李肇端

The effect of intrathecal midazolam on anagesia efficacy of spinal anaesthesia in patients undergoing gynecologic surgery

  • Received:2011-12-07 Revised:2012-04-07 Published:2012-12-15 Online:2012-12-15
  • Contact: Zhao-duan Li

PDF (PC)

1964

摘要： 摘要 目的：比较鞘内注射布比卡因复合咪唑安定对妇科手术蛛网膜下腔麻醉效果的影响。方法：86例择期行子宫肌瘤切除术患者随机分为2组，每组43例。A组蛛网膜下腔给予0.5%布比卡因3.0 mL+0.4 mL生理盐水；B组给予0.5%布比卡因3.0 mL+0.4 mL咪唑安定（2 mg）。观察2组躯体感觉/运动阻滞开始时间、持续时间以及术后不良反应等。结果： B组感觉阻滞持续时间较A组延长，差异有统计学意义(P<0.05)，但2组运动阻滞时间、持续时间及镇静评分差异无统计学意义（P > 0.05)。但B组恶心呕吐发生率低于A组，差异有统计学意义(P <0.05)。结论：鞘内注射布比卡因复合2 mg咪唑安定可延长麻醉镇痛时间，减少不良反应，但不延长运动阻滞时间。

关键词: 镇痛, 布比卡因, 鞘内注射, 咪唑安定

Abstract: Abstract Objective ：To assess the subarachnoid block anesthesia effect of intrathecal bupivacaine and midazolam on patients undergoing gynecologic operation. Methods： A total of 86 patients scheduled for elective myomectomy procedures were selected to participate in this study. According to random number table, patients were allocated into two groups and each group was 43 cases. Group A received 3 mL 0.5% bupivacaine with 0.4mL saline, and group B received 3 mL 0.5 % bupivacaine and 0.4 mL (2mg) midazolam mixture. The onset, duration of sensory/motor block, sedation score and side effects were observed in the experiment. Results： Compared with group A, the duration of sensory blockade was prolonged in the group B(midazolam group), p<0.05, while the time and duration of motor blockade and sedation score were comparable. However he rate of nausea and vomiting has significant difference(p<0.05).Conclusion： Intrathecal bupivacaine with 2mg midazolam resulted in prolonged postoperative analgesia and decreased the adverse effect without increasing motor block time. Key words：analgesia; bupivacaine; intrathecal injection; midazolam

Key words: analgesia, bupivacaine, intrathecal injection, midazolam