天津医药

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妊娠期肾病综合征患者血液高凝状态的研究

高秀霞1,孔祥玲1,张若青2   

  1. 1. 天津武警后勤学院附属医院妇产科
    2. 北京军区天津疗养院
  • 收稿日期:2011-12-20 修回日期:2012-05-08 出版日期:2012-12-15 发布日期:2012-12-15
  • 通讯作者: 高秀霞

A Study of Hypercoagulation State in Nephrotic Syndrome of Pregnancy

  • Received:2011-12-20 Revised:2012-05-08 Published:2012-12-15 Online:2012-12-15

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摘要： 摘要：目的 探讨妊娠期肾病综合征患者血液高凝状态的严重程度。方法 对比分析63例妊娠期肾病综合征患者及201例重度子痫前期患者的凝血指标及血液流变学指标。结果　与重度子痫前期患者比较，妊娠期肾病综合征患者凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）缩短，抗凝血酶Ⅲ(AT-Ⅲ)减少，D-二聚体(D-D)、纤维蛋白原(FIB)增高，差异有统计学意义（P<0.05）。血液粘度(ηb)、血浆粘度(ηp)、全血还原粘度(ηr)、红细胞压积(HCT)、红细胞聚集系数(VAI)及血栓形成系数(TFL)增高，红细胞变形系数(DI)降低，差异有统计学意义（P<0.05）。结论 妊娠期肾病综合征较之单纯重度子痫前期患者有着更为严重的血液高凝状态。

关键词: 妊娠肾病综合征, 重度子痫前期, 高凝状态, 血液流变学

Abstract: Abstract：Objective To study the hypercoagulation state in nephrotic syndrome of pregnancy . Methods Coagulation and hemorrheology indexes were tested and analyzed contrastivly between 63 patients of nephrotic syndrome of pregnancy and 201 patients of severe pre-eclampsia. Results Compared with patients of severe pre-eclampsia,prothrombin time（PT）and activated partialthromboplastin time（APTT）were longer,D-dimer (D-D)and fibrinogen (FIB)were lower and antithrombin Ⅲ(AT-Ⅲ) increased,and blood viscosity(ηb)、plasma specific viscosity (ηp)、whole blood reduced viscosity (ηr)、hematocrit (HCT)、erythrocyte aggregation index (VAI)and thrombosis index(TFL)increased，erythrocyte deformability index(DI) decreased in patients of nephrotic syndrome of pregnancy.The differents were significant（P<0.05）.Conclusion The hypercoagulation state of nephrotic syndrome of pregnancy was more severer than commonly pre-eclampsia.

Key words: Nephrotic syndrome of pregnancy, Severe pre-eclampsia, Hypercoagulation, Hemorrheology