天津医药

• 药物临床观察 •    

复发苦参注射液配合同期放化疗治疗局部晚期鼻咽癌的临床观察

费新雄   

  1. 湖北省黄石市肿瘤医院肿内1科
  • 收稿日期:2012-03-19 修回日期:2012-07-07 出版日期:2012-12-15 发布日期:2012-12-15
  • 通讯作者: 费新雄

Observation of the Clinical efficacy of Kushen Injection Combined with Concurrent Chemoradiotherapy in Locally Advanced Nasopharyngeal Carcinoma Clinical

  • Received:2012-03-19 Revised:2012-07-07 Published:2012-12-15 Online:2012-12-15

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摘要： 摘要 目的：观察复方苦参注射液配合同期放化疗治疗局部晚期鼻咽癌的近期临床疗效和毒副作用。方法：选取2006年10月～2011年11月于我院初治的120例局部晚期鼻咽癌患者随机分为苦参组（60例）和对照组（60例），2组均给予同期放化疗，苦参组同期放化疗开始时加用复方苦参注射液。结果：苦参组完全缓解率较对照组低，差异无统计学意义（P>0.05）。苦参组的副作用明显低于对照组，苦参组生活质量优于对照组，差异有统计学意义（P<0.05）。结论：复方苦参注射液虽未能提高同期放化疗疗效，但能减轻同期放化疗引起的副作用，提高生活质量，促成放化疗顺利完成。

关键词: 鼻咽癌, 同期放化疗, 复方苦参注射液

Abstract: Abstract Objective To observe the recent adjuvant clinical efficacy and side effects of Compound kushen injection in treating with locally advanced nasopharyngeal carcinoma patients undergoing concurrent chemoradiotherapy. Methods 120 patients with locally advanced nasopharyngeal carcinoma for initial treatment in our hospital from October, 2006 to November, 2011 were randomly divided into two groups: the kushen group (n=60) and the control group (n=60). Both groups were treated with concurrent chemoradiotherapy, and the kushen group was given compound kushen injection in addition. Results There were no significant differences (P>0.05) between the complete response rates in the kushen group and the control group. The side effects in the kushen group were significantly lower than those in the control group, and the quality of life in the kushen group were better than that in the control group (P <0.05) Conclusion The compound kushen injection could not improve the clinical efficacy, but it could alleviate the side effects caused by concurrent chemoradiotherapy so as to improve the quality of life and to facilitate completing chemoradiotherapy.

Key words: nasopharyngeal carcinoma, concurrent chemoradiotherapy, compound kushen injection