天津医药

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夫精宫腔内人工授精妊娠率的影响因素分析

秘祖霞,徐雯,卢伟英,马燕琳,张毅,黄元华   

  1. 海南医学院附属医院
  • 收稿日期:2012-02-20 修回日期:2012-10-15 出版日期:2013-03-15 发布日期:2013-03-15
  • 通讯作者: 黄元华

Analysis on Factors Influencing the Pregnancy Rate of Intrauterine Insemination with Husband Sperm

  • Received:2012-02-20 Revised:2012-10-15 Published:2013-03-15 Online:2013-03-15

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摘要：

【摘要】目的 探讨夫精宫腔内人工授精(IUI)妊娠率的相关影响因素。方法 回顾性分析3 998个IUI周期，对女方年龄、不孕年限等因素与临床妊娠率的关系进行统计分析。结果 3 093例患者行3 998个IUI周期，有547例获临床妊娠，周期妊娠率为13.7%。不同年龄、不孕年限、IUI周期数、治疗方案、前向精子数量、授精时机、优势卵泡直径间周期妊娠率差异均有统计学意义，而不同不孕类型、不孕原因、输卵管通畅状况、子宫内膜厚度、内膜类型各组间周期妊娠率差异均无统计学意义(P > 0.05)。非条件多因素逐步Logistic回归分析显示女方年龄增加、IUI周期数较多为IUI 结局的危险因素，而HMG方案与来曲唑方案、前向运动精子数量(5～10)×106条及输卵管通畅为IUI结局的保护因素。结论 女性年龄、IUI周期数、治疗方案、前向运动精子数量及输卵管通畅状况为影响IUI妊娠率的重要因素。

关键词: 人工授精, 妊娠率, 年龄

Abstract: [Abstract] Objective  To investigate the various factors that affect pregnancy rate following intrauterine insemination (IUI) with husband sperm. Methods  A total of 3 998 IUI cycles were retrospectively evaluated. The correlation between pregnancy rate and following factors were analyzed including female age and duration of infertility. Results  A total of 3 093 infertile couples were treated with 3 998 cycles of IUI. Five hundred and forty-seven cases conceived the clinical pregnancy during the study. The pregnancy rate was 13.7% per cycle. There were significant differences in female age, duration of infertility, IUI cycles, ovulation protocol, progressive sperm quantity, timing of IUI and diameter of the leading follicular. There were no significant differences in different types of infertility, different causes of infertility, tubal patency, endometrial thickness and endometrium type (P > 0.05). Results of non-conditional stepwise regression analysis showed that the increase of female age and number of IUI cycles were risk factors of IUI outcome. Meanwhile, the stimulating protocol (HMG group and Le? trozole group), progressive sperm quantity (5×106-10×106group) and tubal patency were protective factors of IUI outcome. Conclusion  The female age, the number of cycles, ovulation protocol, progressive sperm quantity and tubal patency are of great importance in the pregnancy rate of IUI cycles.

Key words: intrauterine insemination (IUI), clinical pregnancy rate, age