天津医药

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尼可胺对H22肝癌荷瘤小鼠的放射增敏作用

王桂亮1,刘晓秋2,韩英3,沈秀3   

  1. 1. 北京协和医学院中国医学科学院放射医学研究所（天津）
    2. 中国医学科学院放射医学研究所
    3.
  • 收稿日期:2010-09-07 修回日期:2010-11-16 出版日期:2011-05-15 发布日期:2011-05-15
  • 通讯作者: 王桂亮

The Radiosensitizing Effects of NiKeAn on H22 Hepatoma-bearing Mices

  • Received:2010-09-07 Revised:2010-11-16 Published:2011-05-15 Online:2011-05-15
  • Contact: Gui-Liang Wang

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摘要： 目的 探讨尼可胺对荷H22肝癌小鼠的放射增敏作用。方法 建立H22肝癌小鼠模型，分为空白对照组、单纯照射组、阳性对照组、尼可胺（高、中、低）组。经照射后，观察H22肝癌小鼠肿瘤生长情况，记录肿瘤照射后生长时间，计算肿瘤生长延缓时间和增敏系数（EF）。照后28天处死小鼠，剥瘤称重，计算抑瘤率。结果 尼可胺高、中、低组，与单纯照射组比，均能增加辐射敏感性，抑制肿瘤的生长，且尼可胺高剂量组的增敏系数（2.13）高于其母体化合物烟酰胺（1.61）和甘氨双唑钠（1.83）。结论 尼可胺对H22肝癌小鼠肿瘤生长有较强的抑制作用，且有较强的放射增敏效果，临床应用前景广阔。

关键词: 尼可胺, H22肝癌小鼠, 放射增敏, 抑瘤率

Abstract: Objective To investigate the radiosensitizing effects of NiKeAn on H22 hepatoma- bearing mice． Methods To establish the mouse hepatoma H22 models which were divided into blank control group, pure radiation group, positive control groups, NiKeAn（high, medium and low）groups． After irradiated, observe the growth of tumor’s conditions, record epigenetic tumor irradiation time, calculated the delay time of tumor growth and enhancement factor（EF）． After 28 days, killed the mouse, stripped tumors and calculated inhibition rate． Results Compared with pure radiation group, NiKeAn （high, medium and low） groups had more significant radiosensitizing effects, and inhibited the tumor growth better．The enhancement factor of NiKeAn high group（2.13）was higher than Sodium Glycididazole group’s and Nicotinamide group’s． Conclusion NiKeAn can inhibite the tumor growth, and has the radiosensitizing effects on H22 hepatoma- bearing mice． It’s clinical practice prospect is broad．

Key words: NiKeAn, H22 hepatoma- bearing mice, Radiosensitization, Inhibition rate．