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原位肝移植术后脾动脉盗血综合征的临床特征分析

李娜   

  1. 天津市第一中心医院
  • 收稿日期:2010-04-19 修回日期:2010-06-24 出版日期:2010-11-15 发布日期:2010-11-15
  • 通讯作者: 李娜

Clinical Characteristics of Splenic Artery Steal Syndrome After Orthotopic Liver Transplantation

li na   

  • Received:2010-04-19 Revised:2010-06-24 Published:2010-11-15 Online:2010-11-15
  • Contact: li na

摘要: 目的:分析原位肝移植术后脾动脉盗血综合征(SASS)的临床表现、诊治方法及治疗疗效。方法:本研究为回顾性系列病例研究。通过病历收集患者的临床资料,包括血常规、肝功能、彩色多普勒超声(CDI)、腹腔动脉-肝动脉造影检查、治疗方法及预后等。结果:共8例SASS患者,男性6例,女性2例,年龄22~55岁,平均43.9岁。确诊时间为4~30天。主要表现为脾功能亢进、肝酶升高。CDI表现为肝动脉流速缓慢、阻力指数较高。腹腔动脉-肝动脉造影表现为脾动脉迂曲、扩张,肝总动脉及其分支显影缓慢,肝内分支稀疏。所有患者均在腹腔动脉-肝动脉造影同时行脾动脉主干钢圈栓塞治疗,栓塞后造影表现为肝总动脉及分支显影速度迅速好转,肝内分支明显清晰。治疗后1dCDI表现为肝动脉流速好转、阻力指数降低。治疗后3d肝功能检查表现为肝酶降低,达到正常范围。随访1月,期间未发生任何并发症。结论:SASS发病率较低,1月内确诊者主要表现为脾功能亢进、肝酶升高。CDI可筛选可疑患者,腹腔动脉-肝动脉造影可用于确诊。脾动脉主干钢圈栓塞治疗SASS安全有效。

关键词: 原位肝移植, 脾动脉盗血综合征, 彩色多普勒超声, 腹腔动脉-肝动脉造影, 脾动脉主干钢圈栓塞

Abstract: Objective: to analyze the clinical characteristics, diagnosis and treatment methods and therapeutic effect of splenic artery steal syndrome. Methods: Retrospective clinical observational cases. All patients with splenic artery steal syndrome underwent examinations with blood routine, liver function, color Doppler image, and celiac angiogram. Results: Eight patients with splenic artery steal syndrome were examined. There were 6 case males and 2 case females. The age of these patients ranged from 22 to 55 years, average 43.9 years. The time of final diagnosis ranged from 4 to 30 days. Clinical signs included hypersplenism and elevated liver enzymes. Color Doppler image showed low hepatic artery velocity and high resistance index. Celiac angiogram showed the hepatic artery was patent but presented with sluggish flow, delayed filling of intrahepatic arterial branches, poor peripheral parenchymal perfusion, associated with early and abundant filling and of the splenic artery. All patients were treated by splenic arterial embolization with coils. The 8 patients improved quickly with significant change in the biochemical and clinical parameters. There were no complications during follow-up period. Conclusion: Splenic artery steal syndrome has low incidence rate. Clinical signs include hypersplenism and elevated liver enzymes. Color Doppler image can be used to screen the patients with splenic artery steal syndrome. Celiac angiogram can be used to diagnose the patients with splenic artery steal syndrome. The patients with splenic artery steal syndrome can be effectively treated by splenic artery embolization with coils.

Key words: orthotopic liver transplantation, splenic artery steal syndrome, color Doppler image, celiac angiogram, transcatheter splenic artery occlusion