天津医药

• 论著 • 上一篇    下一篇

嗅觉事件相关电位及磁共振成像对嗅觉功能的评估

杭伟1,刘钢1,张金玲2,于焕新1   

  1. 1. 天津市环湖医院
    2. 天津市环湖医院耳鼻喉
  • 收稿日期:2011-09-21 修回日期:2011-11-21 出版日期:2012-05-15 发布日期:2012-05-15
  • 通讯作者: 杭伟

Olfactory function assessed with magnetic resonance imaging and olfactory event–related potential

  • Received:2011-09-21 Revised:2011-11-21 Published:2012-05-15 Online:2012-05-15

PDF (PC)

2338

摘要： 摘要 目的: 探讨嗅觉事件相关电位(OERP)和磁共振成像（MRI）对嗅觉功能的评估价值。 方法: 回顾性分析4组44例受试者的临床资料。其中1组为11例嗅觉正常的受试者（NL组），33例嗅觉障碍患者分为3组：①11例慢性鼻窦炎伴息肉（NP组）；②11例颅脑外伤(PT组)；③11例上呼吸道感染后（PI组）。所有受试者均行耳鼻喉科一般检查、鼻内镜检查、T&T嗅觉计定量检查、OERP测试及MRI测量嗅球体积等检查。 结果: T&T嗅觉检查：NL组分数明显高于其他3组，有显著统计学差异。NP、PT、PI 3组间差异无统计学意义。OERP测试：NL组11例、NP组3例、PT组3例、PI组4例可以测出波形，失嗅者无法测出波形。NL组的各波波幅高于其他3组，潜伏期短于其他3组。MRI嗅球体积成像：NL组嗅球体积明显大于其他3组， PT组嗅球体积明显小于NP、PI组，均有显著统计学差异。NP、PI组差异无统计学意义。 结论: OERP能对嗅觉进行定性、定量分析。MRI通过嗅球体积的变化，可对嗅觉进行定量评估。

关键词: 嗅觉障碍, 嗅觉事件相关电位, 磁共振成像, 嗅球体积

Abstract: Abstract Objective: Using olfactory event related potential (OERP) and magnetic resonance imaging (MRI) to evaluate olfactory function. Methods: Eleven healthy individuals with normal olfactory function (NL) and 11 patients with nasal polyposis (NP), 11 with posttraumatic olfactory loss (PT), and 11 with postinfectious olfactory loss(PI) were included in this study.Physical examination,nasal endoscopy, T&T olfactory testing, olfactory event related potentials and magnetic resonance imaging were performed in all patients. Results: T&T olfactory testing revealed that NL individuals had higher scores than patients with NP,PT, or PI. OERP testing were recorded in the 11 NL individuals and in 3 NP, 3 PT, and 4 PI patients. The OB volumes were higher in NL individuals compared with NP, PT, and PI patients. The OB volumes in PT patients were significantly lower than those from NP and PI patients. Conclusion: This finding suggests that these diagnostic tools provide information in terms of the clinical assessment of olfactory function.

Key words: Olfaction disorders, Olfactory event-related potential, Magnetic resonance imaging, Olfactory bulb volume