Abstract: Objective To assess the effect of hemoperfusion (HP) and hemodiafiltration (HDF) on elimination of parathyroid hormone (PTH) from plasma in long- term hemodialysis patients.Methods MEDLINE (1966—2013.8), Embase(1974—2013.8), Chinese Wanfang database (1996—2013.8） ,CNKI（1979—2013.8） and the clinical control test database of Cochrane Library were searched． Published reports, unpublished studies and abstract from conference were retrieved manually, all of which include studies of effect of PTH elimination through hemoperfusion and hemodiafiltration. Quality assessment and data mining were conducted by two independent investigators who performed meta-analysis using RevMan 5.2. Results A total of 12 reports (400 patients) met the inclusion criteria and were included in this study. The meta-analysis showed that the elimination rate of PTH in long term hemodialysis patients was similar between using hemoperfusion and using hemodiafiltration（WMD=-0.34， 95%CI： -12.66-11.98， P=0.96） . What’ s more the elimination rate of β2-MG were also similar（WMD=-2.92， 95%CI： -16.64-10.8， P=0.68）between those two treatments. However， The remission rate of pruritus
was higher in patients using HP group than in HDF group(RR=1.33， 95%CI： 1.08-1.62， P=0.006). Conclusion HP and HDF can effectively clear PTH in chronic hemodialysis patients, but there was no statistically different between the two treatment methods.

Key words: parathyroid hormone, renal dialysis, hemofiltration, Meta-analysis, end-stage renal disease