心肌应变检测技术在非酒精性脂肪性肝病心肌损伤中的研究进展

doi:10.11958/20221772

天津医药 ›› 2023, Vol. 51 ›› Issue (8): 888-891.doi: 10.11958/20221772

心肌应变检测技术在非酒精性脂肪性肝病心肌损伤中的研究进展

马运婷(), 郑月, 王璐静, 沙立辉, 赵新湘^△()

昆明医科大学第二附属医院放射科（邮编650101）

收稿日期:2022-11-03 修回日期:2023-01-13 出版日期:2023-08-15 发布日期:2023-08-10
通讯作者: ^△E-mail：zhaoxinxiang2918@outlook.com
作者简介:马运婷（1995），女，硕士在读，主要从事心肌磁共振方面研究。E-mail：973060735@qq.com
基金资助:
国家自然科学基金资助项目(82160332);云南省重大专项项目(202203AC100007);昆明医科大学联合专项-重点项目(202201AY070001-097)

Research progress of myocardial strain detection technique in myocardial injury of non-alcoholic fatty liver disease

MA Yunting(), ZHENG Yue, WANG Lujing, SHA Lihui, ZHAO Xinxiang^△()

Department of Radiology, the Second Affiliated Hospital of Kunming Medical University, Kunming 650101, China

Received:2022-11-03 Revised:2023-01-13 Published:2023-08-15 Online:2023-08-10
Contact: ^△E-mail: zhaoxinxiang2918@outlook.com

马运婷, 郑月, 王璐静, 沙立辉, 赵新湘. 心肌应变检测技术在非酒精性脂肪性肝病心肌损伤中的研究进展[J]. 天津医药, 2023, 51(8): 888-891.

MA Yunting, ZHENG Yue, WANG Lujing, SHA Lihui, ZHAO Xinxiang. Research progress of myocardial strain detection technique in myocardial injury of non-alcoholic fatty liver disease[J]. Tianjin Medical Journal, 2023, 51(8): 888-891.

摘要/Abstract

摘要：

非酒精性脂肪性肝病（NAFLD）可导致心肌损伤，是心功能不全的危险因素。心肌应变（MS）检测技术是近年快速发展的新技术，已成为量化心肌形变、诊断及预测亚临床心肌损伤的常用工具。MS不仅能准确评估局部和整体心肌损伤，还能检测出射血分数正常的NAFLD患者心功能改变。认识NAFLD造成的心肌损伤，通过MS检测技术及时检测、诊断及预测NAFLD患者心功能障碍，对预防NAFLD患者进展为不可逆心力衰竭具有重要临床意义。就NAFLD造成心肌损伤的病理生理机制、MS检测技术及MS检测技术在NAFLD患者心房心室中的运用进行综述。

关键词: 非酒精性脂肪肝病, 超声心动描记术, 多普勒, 磁共振血管造影术, 心肌应变, 心肌损伤

Abstract:

Non-alcoholic fatty liver disease (NAFLD) can lead to myocardial damage and is a risk factor for cardiac insufficiency. Myocardial strain (MS) detection is a new technique that has been rapidly developed in recent years and has become a common tool for quantifying myocardial deformation and diagnosing and predicting subclinical myocardial injury. MS can not only accurately assess local and global myocardial injury, but also detect changes of cardiac function in NAFLD patients with normal ejection fraction. Understanding myocardial injury caused by NAFLD, timely detection, diagnosis and prediction of cardiac dysfunction in patients with NAFLD by MS detection technique are of great clinical significance in preventing the progression of irreversible heart failure. This article reviews the pathophysiological mechanisms of myocardial injury caused by NAFLD, MS detection techniques and the use of MS detection techniques in atria and ventricle in patients with NAFLD.

Key words: non-alcoholic fatty liver disease, echocardiography, doppler, magnetic resonance angiography, myocardial strain, myocardial damage

中图分类号:

R455.1，R445.2

参考文献 35

[1]	HUANG D Q, EL-SERAG H B, LOOMBA R. Global epidemiology of NAFLD-related HCC:trends,predictions,risk factors and prevention[J]. Nat Rev Gastroenterol Hepatol, 2021, 18(4):223-238. doi:10.1038/s41575-020-00381-6.
[2]	TARGHER G, COREY K E, BYRNE C D. NAFLD, and cardiovascular and cardiac diseases:factors influencing risk,prediction and treatment[J]. Diabetes Metab, 2021, 47(2):101215. doi:10.1016/j.diabet.2020.101215.
[3]	TARGHER G, BYRNE C D, TILG H. NAFLD and increased risk of cardiovascular disease:clinical associations,pathophysiological mechanisms and pharmacological implications[J]. Gut, 2020, 69(9):1691-1705. doi:10.1136/gutjnl-2020-320622.
[4]	RIJZEWIJK L J, JONKER J T, VAN DER MEER R W, et al. Effects of hepatic triglyceride content on myocardial metabolism in type 2 diabetes[J]. J Am Coll Cardiol, 2010, 56(3):225-233. doi:10.1016/j.jacc.2010.02.049.
[5]	HOUGHTON D, ZALEWSKI P, HALLSWORTH K, et al. The degree of hepatic steatosis associates with impaired cardiac and autonomic function[J]. J Hepatol, 2019, 70(6):1203-1213. doi:10.1016/j.jhep.2019.01.035.
[6]	KARAYANNIS G, KITSIOS G, KOTIDIS H, et al. Left atrial remodelling contributes to the progression of asymptomatic left ventricular systolic dysfunction to chronic symptomatic heart failure[J]. Heart Fail Rev, 2008, 13(1):91-98. doi:10.1007/s10741-007-9021-6.
[7]	TARGHER G, MANTOVANI A, GRANDER C, et al. Association between non-alcoholic fatty liver disease and impaired cardiac sympathetic/parasympathetic balance in subjects with and without type 2 diabetes-The Cooperative Health Research in South Tyrol (CHRIS)-NAFLD sub-study[J]. Nutr Metab Cardiovasc Dis, 2021, 31(12):3464-3473. doi:10.1016/j.numecd.2021.08.037.
[8]	LIU B, LI Y, LI Y, et al. Association of epicardial adipose tissue with non-alcoholic fatty liver disease:a meta-analysis[J]. Hepatol Int, 2019, 13(6):757-765. doi:10.1007/s12072-019-09972-1.
[9]	FRACANZANI A L, PISANO G, CONSONNI D, et al. Epicardial Adipose Tissue (EAT) Thickness is associated with cardiovascular and liver damage in nonalcoholic fatty liver disease[J]. PLoS One, 2016, 11(9):e0162473. doi:10.1371/journal.pone.0162473.
[10]	王月, 吴艳凯, 崔彩霞, 等. 心脏MRI应变技术评估高血压患者左室功能[J]. 中国医学影像技术, 2021, 37(5):689-693.
	WANG Y, WU Y K, CUI C X, et al. Cardiac MRI strain technique for evaluation on left ventricular function in patients with hypertension[J]. Chin J med imaging technol, 2021, 37(5):689-693. doi:10.13929/j.issn.1003-3289.2021.05.012.
[11]	WANG R, FANG Z, WANG H, et al. Quantitative analysis of three-dimensional left ventricular global strain using coronary computed tomography angiography in patients with heart failure:comparison with 3T cardiac MR[J]. Eur J Radiol, 2021, 135:109485. doi:10.1016/j.ejrad.2020.109485.
[12]	LI N, LIU T, LIU J, et al. Quantifying myocardial strain of the left ventricle in normal people using feature-tracking based on computed tomography imaging[J]. Diagnostics, 2022, 12(2):329. doi:10.3390/diagnostics12020329.
[13]	LAMACIE M M, THAVENDIRANATHAN P, HANNEMAN K, et al. Quantification of global myocardial function by cine MRI deformable registration-based analysis:comparison with MR feature tracking and speckle-tracking echocardiography[J]. Eur Radiol, 2017, 27(4):1404-1415. doi:10.1007/s00330-016-4514-0.
[14]	马亚南, 孟庆超, 王涵, 等. CT测量左室心肌应变的可重复性及与超声对照的一致性研究[J]. 中华放射学杂志, 2021, 55(11):1147-1152.
	MA Y N, MENG Q C, WANG H, et al. The reproducibility of left ventricular strain measured by CT and its agreement with speckle tracking echocardiography[J]. Chin J Radiol, 2021, 55(11):1147-1152. doi:10.3760/cma.j.cn112149-20210209-00115.
[15]	MILITARU S, PANOVSKY R, HANET V, et al. Multivendor comparison of global and regional 2D cardiovascular magnetic resonance feature tracking strains vs tissue tagging at 3T[J]. J Cardiovasc Magn Reson, 2021, 23(1):54. doi:10.1186/s12968-021-00742-3.
[16]	BAKTIR A O, ŞARLI B, ALTEKIN R E, et al. Non alcoholic steatohepatitis is associated with subclinical impairment in left ventricular function measured by speckle tracking echocardiography[J]. Anatol J Cardiol, 2015, 15(2):137-142. doi:10.5152/akd.2014.5212.
[17]	ALTEKIN R E, CAGLAR B, KARAKAS M S, et al. Evaluation of subclinical left ventricular systolic dysfunction using two-dimensional speckle-tracking echocardiography in patients with non-alcoholic cirrhosis[J]. Hellenic J Cardiol, 2014, 55(5):402-410.
[18]	KARABAY C Y, KOCABAY G, KALAYCI A, et al. Impaired left ventricular mechanics in nonalcoholic fatty liver disease:a speckle-tracking echocardiography study[J]. Eur J Gastroenterol Hepatol, 2014, 26(3):325-331. doi:10.1097/MEG.0000000000000008.
[19]	LEUNG D Y, NG A C. Emerging clinical role of strain imaging in echocardiography[J]. Heart Lung Circ, 2010, 19(3):161-174. doi:10.1016/j.hlc.2009.11.006.
[20]	VOIGT J U, CVIJIC M. 2- and 3-Dimensional myocardial strain in cardiac health and disease[J]. JACC Cardiovasc Imaging, 2019, 12(9):1849-1863. doi:10.1016/j.jcmg.2019.01.044.
[21]	EL AMROUSY D, ELGENDY E, AWAD M E, et al. Three-dimensional speckle tracking echocardiography for early detection of left ventricular dysfunction in children with non-alcoholic fatty liver diseases[J]. Cardiol Young, 2021, 31(4):562-567. doi:10.1017/S104795112000445X.
[22]	WANG Q, MA W, XIA J. Nonalcoholic Fatty Liver Is Associated with further left ventricular abnormalities in patients with type 2 diabetes mellitus:a 3-dimensional speckle-tracking study:nonalcoholic fatty liver and left ventricular abnormalities in type 2 diabetes[J]. J Ultrasound Med, 2018, 37(8):1899-1911. doi:10.1002/jum.14536.
[23]	SONAGLIONI A, CERINI F, CERRONE A, et al. Liver stiffness measurement identifies subclinical myocardial dysfunction in non-advanced non-alcoholic fatty liver disease patients without overt heart disease[J]. Intern Emerg Med, 2022, 17(5):1425-1438. doi:10.1007/s11739-022-02966-2.
[24]	DONG Y, CUI H, SUN L, et al. Assessment of left ventricular function in type 2 diabetes mellitus patients with non-alcoholic fatty liver disease by three-dimensional speckle-tracking echocardiography[J]. Anatol J Cardiol, 2020, 23(1):41-48. doi:10.14744/AnatolJCardiol.2019.66805.
[25]	VANWAGNER L B, WILCOX J E, NING H, et al. Longitudinal association of non-alcoholic fatty liver disease with changes in myocardial structure and function:the cardia study[J]. J Am Heart Assoc, 2020, 9(4):e014279. doi:10.1161/JAHA.119.014279.
[26]	SONAGLIONI A, CERINI F, NICOLOSI G L, et al. Left ventricular strain predicts subclinical atherosclerosis in nonadvanced nonalcoholic fatty liver disease patients[J]. Eur J Gastroenterol Hepatol, 2022, 34(6):707-716. doi:10.1097/MEG.0000000000002375.
[27]	CHANG W, WANG Y, SUN L, et al. Evaluation of left atrial function in type 2 diabetes mellitus patients with nonalcoholic fatty liver disease by two‐dimensional speckle tracking echocardiography[J]. Echocardiography, 2019, 36(7):1290-1297. doi:10.1111/echo.14400.
[28]	KOCABAY G, KARABAY C Y, COLAK Y, et al. Left atrial deformation parameters in patients with non-alcoholic fatty liver disease:a 2D speckle tracking imaging study[J]. Clin Sci (Lond), 2014, 126(4):297-304. doi:10.1042/CS20130298.
[29]	LAI Y H, SU C H, HUNG T C, et al. Association of non-alcoholic fatty liver disease and hepatic fibrosis with epicardial adipose tissue volume and atrial deformation mechanics in a large asian population free from clinical heart failure[J]. Diagnostics (Basel), 2022, 12(4):916. doi:10.3390/diagnostics12040916.
[30]	BEKLER A, GAZI E, ERBAG G, et al. Right ventricular function and its relationship with grade of hepatosteatosis in non-alcoholic fatty liver disease[J]. Cardiovasc J Afr, 2015, 26(3):109-113. doi:10.5830/CVJA-2014-068.
[31]	SUNBUL M, KIVRAK T, DURMUS E, et al. Nonalcoholic steatohepatitis score is an independent predictor of right ventricular dysfunction in patients with nonalcoholic fatty liver disease[J]. Cardiovasc Ther, 2015, 33(5):294-299. doi:10.1111/1755-5922.12145.
[32]	TEN HOVE M, NEUBAUER S. MR spectroscopy in heart failure—clinical and experimental findings[J]. Heart Fail Rev, 2007, 12(1):48-57. doi:10.1007/s10741-007-9003-8.
[33]	HALLSWORTH K, HOLLINGSWORTH K G, THOMA C, et al. Cardiac structure and function are altered in adults with non-alcoholic fatty liver disease[J]. J Hepatol, 2013, 58(4):757-762. doi:10.1016/j.jhep.2012.11.015.
[34]	RÜSSEL I K, BROUWER W P, GERMANS T, et al. Increased left ventricular torsion in hypertrophic cardiomyopathy mutation carriers with normal wall thickness[J]. J Cardiovasc Magn Reson, 2011, 13(1):3. doi:10.1186/1532-429X-13-3.
[35]	HAMMOUDA K, KHALIFA F, ABDELTAWAB H, et al. A new framework for performing cardiac strain analysis from cine MRI imaging in mice[J]. Sci Rep, 2020, 10(1):7725. doi:10.1038/s41598-020-64206-x.

心肌应变检测技术在非酒精性脂肪性肝病心肌损伤中的研究进展

Research progress of myocardial strain detection technique in myocardial injury of non-alcoholic fatty liver disease

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