天津医药

天津医药 ›› 2024, Vol. 52 ›› Issue (9): 936-939.doi: 10.11958/20231979

• 临床研究 • 上一篇    下一篇

1 565 nm非剥脱点阵激光在雄激素性秃发中的临床疗效观察

程毅(), 徐亚萍, 吕丽璟, 崔瑜, 张燕, 胡彩霞△()   

  1. 河北医科大学第四医院皮肤科（邮编050000）
  • 收稿日期:2024-01-02 修回日期:2024-04-10 出版日期:2024-09-15 发布日期:2024-09-06
  • 通讯作者: △E-mail：48201485@hebmu.edu.cn
  • 作者简介:程毅（1984），女，副主任医师，主要从事皮肤疾病诊疗方面研究。E-mail：48401985@hebmu.edu.cn
  • 基金资助:
    河北省自然科学基金委基金资助项目(H2021206253)

Clinical efficacy of 1 565 nm non-ablative fractional laser in androgenetic alopecia

CHENG Yi(), XU Yaping, LYU Lijing, CUI Yu, ZHANG Yan, HU Caixia△()   

  1. Department of Dermatology, the Forth Hospital of Hebei Medical University, Shijiazhuang 050000, China
  • Received:2024-01-02 Revised:2024-04-10 Published:2024-09-15 Online:2024-09-06
  • Contact: △E-mail：48201485@hebmu.edu.cn

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摘要：

目的 探讨1 565 nm非剥脱点阵激光联合外用米诺地尔及口服非那雄胺治疗雄激素性秃发（AGA）患者的效果及安全性。方法 将75例Hamilton-Norwood分级Ⅱ—Ⅲ级男性AGA患者随机分为对照组1、对照组2和试验组，各25例。对照组1给予外用5%米诺地尔酊治疗，对照组2在对照组1基础上同时口服非那雄胺片，试验组除上述口服及外用治疗外，进行1 565 nm非剥脱点阵激光治疗。在治疗前和治疗第24周时，采用7点总体评分量表评价毛发总体疗效；皮肤毛发镜测定毛发直径和毛发密度。治疗后调查患者满意度，并记录不良反应的发生情况。结果 试验组毛发总体疗效优于对照组1和对照组2。治疗前，3组患者毛发直径和毛发密度差异均无统计学意义（P>0.05）；治疗后，3组患者毛发直径和毛发密度均升高，试验组治疗后毛发直径和毛发密度均高于对照组1和对照组2（P<0.05）。试验组患者满意度优于对照组1和对照组2。试验组患者行激光治疗时出现可耐受的疼痛及灼烧感，症状均于数小时内自行缓解，各组均无严重不良反应发生。结论 1 565 nm非剥脱点阵激光、5%米诺地尔和非那雄胺联合疗法治疗AGA的疗效明显优于单纯使用米诺地尔和非那雄胺药物治疗。

关键词: 秃发, 米诺地尔, 非那雄胺, 点阵激光, 雄激素性秃发, 毛乳头

Abstract:

Objective To investigate the clinical efficacy and safety of 1 565 nm non-ablative fractional laser combined with topical minoxidil and oral finasteride in the treatment of patients with androgenetic alopecia (AGA). Methods Seventy-five male AGA patients with Norwood-Hamilton classification grade Ⅱ-Ⅲ, were randomly assigned into three groups: the control group 1, the control group 2 and the experimental group, with 25 cases in each group. Patients in the control group 1 received topical 5% minoxidil (1 mL, twice daily). Patients in the control group 2 were treated with both topical 5% minoxidil and oral finasteride (1 mg, once daily). Patients in the experimental group received a combined therapy of 1 565 nm non-ablative fractional laser in addition to topical 5% minoxidil and oral finasteride. Hair overall efficacy was evaluated using a 7-point rating scale after 24 weeks of treatment. Hair diameter and density were measured using a dermoscope. Patient satisfaction was assessed post-treatment, and adverse reactions were recorded. Results The overall efficacy of hair in the experimental group was superior to the control group 1 and the control group 2. There were no significant differences in hair density and hair diameter before treatment between the three groups (P>0.05). After treatment, hair diameter and density increased in all three groups compared to baseline values (P<0.05), and the hair diameter and hair density of the experimental group were higher than those of the control group 1 and the control group 2 (P<0.05). Patient satisfaction in the experimental group was higher than that in the control group 1 and the control group 2 (P<0.05). Patients in the experimental group experienced tolerable pain and burning sensations during laser treatment, and the symptoms were self-alleviated within a few hours. There were no serious adverse reactions reported in any group. Conclusion The combination therapy of 1 565 nm non-ablative fractional laser, 5% minoxidil, and finasteride demonstrates significantly better efficacy in the treatment of AGA than minoxidil and finasteride alone drug therapy.

Key words: alopecia, minoxidil, finasteride, fractional laser, androgenic alopecia, dermal papilla

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