天津医药

天津医药 ›› 2025, Vol. 53 ›› Issue (6): 614-618.doi: 10.11958/20250665

• 临床研究 • 上一篇    下一篇

18F-PSMA-1007 PET/CT的SUVmax和SUVmean参数对前列腺癌诊断及病情进展的预测价值

王海诚1(), 赵一涵1, 谢妹伊2, 赵宇明1,△()   

  1. 1 秦皇岛市第一医院泌尿外科（邮编066000）
    2 秦皇岛市第一医院护理部（邮编066000）
  • 收稿日期:2025-02-19 修回日期:2025-03-25 出版日期:2025-06-15 发布日期:2025-06-20
  • 通讯作者: △E-mail：zym19820111@163.com
  • 作者简介:王海诚（1989），男，主治医师，主要从事泌尿系统肿瘤、结石和良性疾病方面研究。E-mail：htxz1210@163.com
  • 基金资助:
    秦皇岛市重点研发计划科技支撑项目(202401A060)

Predictive value of SUVmax and SUVmean parameters in 18F-PSMA-1007 PET/CT for the diagnosis and disease progression of prostate cancer

WANG Haicheng1(), ZHAO Yihan1, XIE Meiyi2, ZHAO Yuming1,△()   

  1. 1 Department of Urinary Surgery, First Hospital of Qinhuangdao, Qinhuangdao 066000, China
    2 Department of Nursing, First Hospital of Qinhuangdao, Qinhuangdao 066000, China
  • Received:2025-02-19 Revised:2025-03-25 Published:2025-06-15 Online:2025-06-20
  • Contact: △E-mail: zym19820111@163.com

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摘要：

目的 探究18F-前列腺特异性膜抗原-1007正电子发射体层成像/计算机体层成像（18F-PSMA-1007 PET/CT）中SUVmax和SUVmean参数对前列腺癌（PCa）诊断及病情进展的预测价值。方法 选取接受18F-PSMA-1007 PET/CT检查的80例疑似PCa患者，按其穿刺病理结果分为PCa组（49例）和非PCa组（31例），收集2组患者入院时18F-PSMA-1007 PET/CT参数最大标准化摄取值（SUVmax）和平均标准化摄取值（SUVmean），入院时和入院3个月后PCa组患者的前列腺特异抗原（PSA）、前列腺癌组织学分级（GLEASON）评分。经受试者工作特征（ROC）曲线分析18F-PSMA-1007 PET/CT参数水平对PCa的诊断效能。Pearson法分析PCa组患者入院时18F-PSMA-1007 PET/CT参数水平与PSA、GLEASON评分的相关性。结果 PCa组的SUVmax、SUVmean值高于非PCa组（P<0.05）；ROC曲线分析显示，SUVmax、SUVmean水平单一指标检测的曲线下面积（AUC）分别为0.887、0.843；敏感度分别为80.65%、83.87%；特异度分别为87.76%、73.47%。PCa组入院3个月后PSA、GLEASON评分低于入院时（P<0.05）；Pearson相关分析显示，入院时PCa组患者的SUVmax和SUVmean分别与入院时和入院3个月后的PSA、GLEASON评分呈正相关（P<0.05）。结论 18F-PSMA-1007 PET/CT的SUVmax和SUVmean参数对PCa的诊断及病情进展有较高预测价值。

关键词: 前列腺肿瘤, 正电子发射断层显像计算机体层摄影术, 18F-PSMA-1007, 诊断, SUVmax, SUVmean

Abstract:

Objective To explore the predictive value of maximum standardized uptake value (SUVmax) and mean standardized uptake value (SUVmean) parameters in 18F-prostate specific membrane antigen-1007 positron emission tomography/computed tomography (18F-PSMA-1007 PET/CT) for the diagnosis and disease progression of prostate cancer (PCa). Methods Eighty patients with suspected PCa who underwent 18F-PSMA-1007 PET/CT examination in the hospital were selected and divided into the PCa group (49 cases) and the non-PCa group (31 cases) according to the biopsy pathological results. The 18F-PSMA-1007 PET/CT parameters were collected in the two groups of patients at admission, including SUVmax and SUVmean. The prostate specific antigen (PSA) and prostate cancer histological grade (GLEASON) score were also collected in patients of the PCa group at admission and 3 months after admission. The diagnostic efficiency of 18F-PSMA-1007 PET/CT parameters on PCa was analyzed by receiver operating characteristic (ROC) curve. The correlation between 18F-PSMA-1007 PET/CT parameters of patients in the PCa group at admission and PSA, GLEASON score was analyzed by Pearson method. Results The SUVmax and SUVmean in the PCa group were higher than those in the non-PCa group (P<0.05). ROC curve analysis showed that the areas under the curves (AUCs) of SUVmax and SUVmean were 0.887 and 0.843 respectively, the sensitivities were 80.65% and 83.87%, and the specificities were 87.76% and 73.47% respectively. The PSA and GLEASON score were lower 3 months after admission than those at admission in the PCa group (P<0.05). Pearson correlation analysis showed that the SUVmax and SUVmean of patients in the PCa group at admission were positively correlated with PSA and GLEASON score at admission and 3 months after admission (P<0.05). Conclusion SUVmax and SUVmean parameters of 18F-PSMA-1007 PET/CT have high predictive value for the diagnosis and disease progression of PCa.

Key words: prostatic neoplasms, positron emission tomography computed tomography, 18F-PSMA-1007, diagnosis, SUVmax, SUVmean

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