天津医药

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2型糖尿病肾病与亚临床炎症因子的关系

崔姗姗,赵伟,张宏,张雅静   

  1. 天津医科大学代谢病医院
  • 收稿日期:2009-12-28 修回日期:2010-03-10 出版日期:2010-10-15 发布日期:2010-10-15
  • 通讯作者: 崔姗姗

Relationship between Diabetic Nephropathy and Subclinial Inflammatory Factors

  • Received:2009-12-28 Revised:2010-03-10 Published:2010-10-15 Online:2010-10-15

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摘要： 摘要 目的：探讨2型糖尿病肾病( DN)患者与血清超敏C反应蛋白（hs-CRP）、外周血白细胞计数（WBC）、血浆纤维蛋白原（FIB）水平的相关性。方法：我院住院的2型DM患者506例分为DN组、非DN组。分别检测、比较二组血清hs-CRP、外周血WBC计数、血浆FIB水平及其与DN的相关性。结果：DN组与非DN组比较，血清hs-CRP、外周血WBC计数、血浆FIB水平显著升高（3.653±4.634vs1.974±2.878; 7.04±1.94vs6.49±1.65; 3.46±0.89vs3.16±0.72,P<0.05），单因素Logistic回归分析显示DN与血清hs-CRP、外周血WBC计数、血浆FIB水平均存在显著正相关（OR=1.127, 95%CI：1.072-1.186；OR=1.188, 95%CI：1.072-1.317; OR=1.630, 95%CI：1.284-2.070），调整了年龄、性别、DM病程、吸烟、血压、血脂、体质指数(BMI)后，血清hs-CRP、外周血WBC计数、血浆FIB水平仍与DN呈显著正相关(OR=1.163，95% CI：1.034-1.308；OR =1.772，95% CI：1.343-2.338；OR=1.144，95% CI：1.082-1.211)。结论：作为亚临床炎症因子的hs—CRP、FIB、WBC与DN的发生密切相关，这些炎症指标可为临床工作中DN的预测和评估病情提供一定的依据。

关键词: 糖尿病, 2型, 糖尿病肾病, C-反应蛋白, 纤维蛋白原, 白细胞

Abstract: Abstract：0bjective To investigate the changes of the levels of high sensitivity reactive protein C (hsCRP), white blood cell (WBC) and fibrinogen (FIB) in diabetic nephropathy(DN) pa- tients. Methods：The clinic documents of 506 patients with type 2 diabetes were divided into two groups based on with／without DN．The changes of the levels of hsCRP，WBC and FIB in the two groups and the relationship between their levels and DN were analyzed．Results:Compared to non-DN group，the levels of hsCRP，WBC，FIB in DN group were increased obviously（3.653±4.634vs1.974±2.878; 7.04±1.94vs6.49±1.65; 3.46±0.89vs3.16±0.72,P<0.05）.Using univariate logistic regression analysis it was found that the nephropathy had a positive correlation with WBC，hsCRP，FIB（OR=1.127, 95%CI：1.072-1.186；OR=1.188, 95%CI：1.072-1.317;OR=1.630, 95%CI：1.284-2.070）.In a multiple logistic regression analysis，after adjusting the age，gender，the ascend duration of diabetes，smoking , blood pressure, lipid and body mass index(BMI)，the levels of WBC，hsCRP，FIB still had a predominant relation with DN(OR=1.163，95% CI：1.034-1.308；OR =1.772，95% CI：1.343-2.338；OR=1.144，95% CI：1.082-1.211). Conclusion :The levels of WBC，hsCRP，FIB are closely related with DN．These subclinical inflammatory index can be used for prognosis and evalutation of DN．

Key words: Diabetes mellitus, type 2, Diabetic nephropathies, Hypersensitivity reactive protein C, Fibrinogen, White blood cell