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2型糖尿病肾病与亚临床炎症因子的关系

崔姗姗,赵伟,张宏,张雅静   

  1. 天津医科大学代谢病医院
  • 收稿日期:2009-12-28 修回日期:2010-03-10 出版日期:2010-10-15 发布日期:2010-10-15
  • 通讯作者: 崔姗姗

Relationship between Diabetic Nephropathy and Subclinial Inflammatory Factors

  • Received:2009-12-28 Revised:2010-03-10 Published:2010-10-15 Online:2010-10-15

摘要: 摘要 目的:探讨2型糖尿病肾病( DN)患者与血清超敏C反应蛋白(hs-CRP)、外周血白细胞计数(WBC)、血浆纤维蛋白原(FIB)水平的相关性。方法:我院住院的2型DM患者506例分为DN组、非DN组。分别检测、比较二组血清hs-CRP、外周血WBC计数、血浆FIB水平及其与DN的相关性。结果:DN组与非DN组比较,血清hs-CRP、外周血WBC计数、血浆FIB水平显著升高(3.653±4.634vs1.974±2.878; 7.04±1.94vs6.49±1.65; 3.46±0.89vs3.16±0.72,P<0.05),单因素Logistic回归分析显示DN与血清hs-CRP、外周血WBC计数、血浆FIB水平均存在显著正相关(OR=1.127, 95%CI:1.072-1.186;OR=1.188, 95%CI:1.072-1.317; OR=1.630, 95%CI:1.284-2.070),调整了年龄、性别、DM病程、吸烟、血压、血脂、体质指数(BMI)后,血清hs-CRP、外周血WBC计数、血浆FIB水平仍与DN呈显著正相关(OR=1.163,95% CI:1.034-1.308;OR =1.772,95% CI:1.343-2.338;OR=1.144,95% CI:1.082-1.211)。结论:作为亚临床炎症因子的hs—CRP、FIB、WBC与DN的发生密切相关,这些炎症指标可为临床工作中DN的预测和评估病情提供一定的依据。

关键词: 糖尿病, 2型, 糖尿病肾病, C-反应蛋白, 纤维蛋白原, 白细胞

Abstract: Abstract:0bjective To investigate the changes of the levels of high sensitivity reactive protein C (hsCRP), white blood cell (WBC) and fibrinogen (FIB) in diabetic nephropathy(DN) pa- tients. Methods:The clinic documents of 506 patients with type 2 diabetes were divided into two groups based on with/without DN.The changes of the levels of hsCRP,WBC and FIB in the two groups and the relationship between their levels and DN were analyzed.Results:Compared to non-DN group,the levels of hsCRP,WBC,FIB in DN group were increased obviously(3.653±4.634vs1.974±2.878; 7.04±1.94vs6.49±1.65; 3.46±0.89vs3.16±0.72,P<0.05).Using univariate logistic regression analysis it was found that the nephropathy had a positive correlation with WBC,hsCRP,FIB(OR=1.127, 95%CI:1.072-1.186;OR=1.188, 95%CI:1.072-1.317;OR=1.630, 95%CI:1.284-2.070).In a multiple logistic regression analysis,after adjusting the age,gender,the ascend duration of diabetes,smoking , blood pressure, lipid and body mass index(BMI),the levels of WBC,hsCRP,FIB still had a predominant relation with DN(OR=1.163,95% CI:1.034-1.308;OR =1.772,95% CI:1.343-2.338;OR=1.144,95% CI:1.082-1.211). Conclusion :The levels of WBC,hsCRP,FIB are closely related with DN.These subclinical inflammatory index can be used for prognosis and evalutation of DN.

Key words: Diabetes mellitus, type 2, Diabetic nephropathies, Hypersensitivity reactive protein C, Fibrinogen, White blood cell