天津医药

• 论著 • 上一篇    下一篇

血浆网膜素水平与代谢综合征的关系研究

张洁1,邸阜生2,王璐1,杨莉1,洪燕青1,刘聪1   

  1. 1. 天津市第三中心医院
    2. 天津市第三中心医院内分泌科
  • 收稿日期:2010-03-30 修回日期:2010-06-17 出版日期:2010-12-15 发布日期:2010-12-15
  • 通讯作者: 张洁

The relationship of Plasma omentin level And Metabolic syndrome

  • Received:2010-03-30 Revised:2010-06-17 Published:2010-12-15 Online:2010-12-15
  • Contact: ZHANG JIE

PDF (PC)

2085

摘要： 目的:探讨2型糖尿病(T2DM)合并代谢综合征(MS)患者血浆网膜素水平的变化。方法:收集T2DM患者95例和正常对照(NC)组36例,将T2DM患者分为T2DM不合并MS组(A组)46例,T2DM合并MS组(B组)49例。采用ELISA检测3组空腹血浆网膜素水平,检测各组血糖、血脂、空腹胰岛素(Fins)、收缩压(SBP)、舒张压(DBP),计算腰臀比(WHR)、体质量指数(BMI),胰岛素抵抗指数(HOMA-IR),并分析各指标与网膜素的关系。结果:血浆网膜素水平NC组最高,A组其次,B组水平最低;其与腰围(WC)、臀围(HC)、BMI、三酰甘油(TG)、空腹血糖(FBG)、75g葡萄糖负荷后2h血糖(2hPG)、Fins、HOMA-IR、SBP、DBP呈负相关(r分别为-0.465、-0.473、-0.814、-0.696、-0.380、-0.635、-0.691、-0.684、-0.663、-0.522,P<0.01),与高密度脂蛋白胆固醇(HDL-C)呈正相关(r=0.279,P<0.01)。BMI、2hPG和WC是空腹血浆网膜素的影响因素。结论:MS患者血浆网膜素水平与胰岛素抵抗和肥胖密切相关,可能在MS的发病过程中起到重要作用。

关键词: 关 键 词 代谢综合征, 2型糖尿病, 网膜素

Abstract: Abstract Objective: We explored the relationships between 2 diabetes mellitus with Metabolic syndrome and plasma omentin level. Methods: Fasting plasma omentin level of T2DM (forty nine patients with Metabolic syndrome ,forty six patients without Metabolic syndrome) were assayed by enzyme-linked immunosorbent asssy(ELISA), and thirty six controls, The relationship of plasma omentin level with blood glucose,blood lipids, FINs, WHR,BMI,HOMA-IR,SBP,DBP were also analyzed. Results：The plasma omentin level was significantly lower than controls（P<0.01）. Plasma omentin level in T2DM with MS was significantly lower than without MS（P<0.01）.correlation analysis showed that the plasma omentin level was negatively in correlation withWC,TG,HOMA-IR ,Fins,2hPG,FBG,SBP,DBP（r=-0.465，-0.696，-0.648，-0.691，-0.635，-0.380，-0.663，-0.522 P<0.01）, and was positively in correlation with HDL（r= 0.279 P<0.01）.Stepwise regression indicated that BMI,2hPG and WC were independent correlation fators that influenced the level of omentin . Conclusion :Omentin was associated with obesity and insulin resistance in patients with MS. It contributes to the process of MS.

Key words: Omentin, Metabolic syndrome, Type 2 diabetes mellitus.