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rhBNP治疗急性心肌梗死伴急性左心衰的临床观察

吴英凤   

  1. 天津市大港油田总医院心血管一科
  • 收稿日期:2011-06-14 修回日期:2011-07-28 出版日期:2011-10-15 发布日期:2011-10-15
  • 通讯作者: 吴英凤

Clinical study of recombinant human brain natriuretic peptide in patients with acute myocardial infarction complicated with acute left heart failure

  • Received:2011-06-14 Revised:2011-07-28 Published:2011-10-15 Online:2011-10-15

摘要: 目的:探讨重组人脑利钠肽在急性心肌梗塞伴急性左心衰治疗中的临床疗效以及可能存在的不良反应。方法:将52例急性心肌梗塞伴急性左心衰的患者,依据治疗方式分为重组人脑利钠肽(rhBNP)组(治疗组30例)和硝酸甘油组(对照组22例),观察所有患者在治疗前及治疗后的临床症状体征改善情况,记录治疗前后的血压、心率、尿量、BNP水平、肾功能及住院时间等指标。结果:治疗组在治疗后心率、尿量、BNP水平等指标上较对照组均有明显改善,差异有统计学意义(P<0.001),而治疗前后两组在血压下降、肾功能恶化方面均无明显差异(P>0.001)。治疗组在患者的临床症状、体征、心功能改善等临床疗效方面,均显著优于对照组。结论:重组人脑利钠肽在治疗急性心梗(AMI)合并急性心衰(AHF)方面显示出其良好的临床作用,可明显改善患者的临床症状及各项指标,其效果明显优于硝酸甘油等传统药物,临床应用安全有效。

关键词: 重组人脑利钠肽, 硝酸甘油, 急性心肌梗塞, 急性左心衰竭

Abstract: Objective: To observe the effect and safety of recombinant human brain natriuretic peptide(rhBNP) in treating patients with acute myocardial infarction complicated acute left heart failure.Method:. Based on different treatment models, fifty-two patients with acute myocardial infarction complicated with acute left heart failure were divided into two groups, one is the recombinant human brain natriuretic peptide(rhBNP) group for 30 cases(treatment group )and the other is nitroglycerin group for 24 cases (control group). All of these patients’ vital signs,clinic status and laboratory data (BP、UV 、HR、BNP 、kidney function and the day of in hospital) were observed at the day before and after treatment. Results:Compared with the control group,the treatment group showed a more improve of HR 、UV and BNP after treatment, the differences were statistical significance(P<0.001). The level of BP , kidney function before and after treatment had no statistical difference(P>0.001).Compared with the control group, the treatment group showed a more improve of clinical effect. Conclusions:The rhBNP can improve heart function of dilatation and contraction and clinical condition with acute myocardial infarction complicated with acute left heart failure obviously,and has reliable and safely effect.The rhBNP is superior to nitroglycerin in treating patients with acute myocardial infarction complicated with acute left heart failure.

Key words: recombinant human brain natriuretic peptide, nitroglycerin, acute myocardial infarction, acute left heart failure