慢性荨麻疹患者血清二胺氧化酶活性和总IgE检测及意义

慢性荨麻疹患者血清二胺氧化酶活性和总IgE检测及意义

张敏¹,李桂珍²,宋蒙蒙³,张理涛²

1. 天津市长征医院
2. 长征医院
3. 天津医大

收稿日期:2011-01-21 修回日期:2011-03-09 出版日期:2011-06-15 发布日期:2011-06-15
通讯作者: 张敏

Detection of Serum Diamine Oxidase Activity in Chronic Urticaria and its Significance

Received:2011-01-21 Revised:2011-03-09 Published:2011-06-15 Online:2011-06-15

张敏1 ,李桂珍2 ,宋蒙蒙3 ,张理涛2 . 慢性荨麻疹患者血清二胺氧化酶活性和总IgE检测及意义[J]. .

摘要/Abstract

摘要： 目的：检测慢性荨麻疹患者血清二胺氧化酶活性变化并与病情程度和评分进行相关性分析，以探讨二胺氧化酶活性改变在慢性荨麻疹发病中的意义。方法：用分光光度法测定68例慢性荨麻疹患者和54例健康对照血清中二胺氧化酶的活性，并将其活性与病情程度和评分进行相关性分析。结果：患者血清二胺氧化酶的活性在1小时、1.5小时和3小时均低于健康对照组，其中1.5小时和3小时的活性与对照组比较差异显著，有统计学意义（P<0.01）；患者DAO活性与其病情的轻、中、重度存在相关性（P<0.05）。结论：慢性荨麻疹患者血清二胺氧化酶活性降低，可能与其慢性病程及严重程度有关。

关键词: 慢性荨麻疹, 二胺氧化酶, 组胺

Abstract: Objective: To detect the serum activity of diamine oxidase in chronic urticaria and analyze its correlation with urticaria severity, so as to explore its significance in the pathogenesis of chronic urticaria. Methods: Serum diamine oxidase activity were determined by spectrophotometry in 68 patients with chronic urticaria and 54 healthy control. The activity and the urticaria severity were compared by using linear correlation. Results: The serum diamine oxidase activity in 1 hour, 1.5 hour and 3 hours was lower than that of healthy control. There were significant difference between 1.5/ 3 hours and control group (P<0.01). The correlation between the activity and the urticaria severity is significant (P<0.05). Conclusion: The serum diamine oxidase activity in chronic urticaria patients decreased, which might be implicated with the chornic pathogenesis and urticaria severity.

Key words: chronic urticaria , diamine oxidase, histamine