拉莫三嗪单药治疗新诊断小儿癫痫的临床疗效分析

拉莫三嗪单药治疗新诊断小儿癫痫的临床疗效分析

程新旺¹,冯占辉²

1. 天津市第一中心医院
2. 贵阳医学院附属第一医院

收稿日期:2012-02-20 修回日期:2012-03-31 出版日期:2012-10-15 发布日期:2012-10-15
通讯作者: 冯占辉

Clinical effects of Lamotrigine monotherapy among children patients with newly diagnosed epilepsy

Received:2012-02-20 Revised:2012-03-31 Published:2012-10-15 Online:2012-10-15

程新旺1 ,冯占辉2 . 拉莫三嗪单药治疗新诊断小儿癫痫的临床疗效分析[J]. .

摘要/Abstract

摘要： 目的：观察拉莫三嗪对新诊断小儿癫痫的疗效和安全性。方法：选取天津市第一中心医院和贵阳医学院附属医院癫痫门诊或住院80例新诊断小儿癫痫患者，给予拉莫三嗪单药治疗。起始剂量0.5mg/(kg?d)，每周增加0.5mg/kg，至第4周加至目标剂量4.0－5.0mg/(kg?d)，分两次口服。观察药物的不良反应及药物疗效。结果：80例患者中完全控制31例，显效27例，有效8例，无效14例，总有效率为82.5％。各发作类型中以强直一阵挛发作疗效最佳，总有效率为95.0％，不良反应以皮疹、头痛、嗜睡较为多见，80例患者中有7例出现上述反应，发生率为8.7％。随着继续用药，症状消失。结论：拉莫三嗪应用治疗小儿癫痫总有效率较高，副作用出现率低，是治疗小儿癫痫的一种安全、有效药物。

关键词: 抗癫痫药物, 拉莫三嗪, 单药治疗

Abstract: Objective: To understand the clinical effective of lamotrigine for Children patients with newly diagnosed epilepsy. Methods: 80 cases of children patients with newly diagnosed epilepsy, were treated with lamotrigine. LTG was used originally at a dose of 0.5mg/(kg?d), 4 weeks achieved the goal dosage (4.0-5.0mg/(kg?d)). We observed their changes of seizure frequencies compared with the basic-line before the treatments. Result: There are 31 patients seizure free, 27 patients whose frequencies were reduced by more than 75%, 8 patients’ frequencies were reduced by more than 50%. The total effective reached 82.5％. Patients with GTCS obtained the best effects. The total effective reached 95.0％. Related adverse effcts included asthenia, somnolence, skin rashes. These adverse effects disappeared spontaneously without any special treatment. Conclusion: lamotrigine is a safe effective drug for Children patients with newly diagnosed epilepsy.

Key words: Antiepilepsy drug, lamotrigine(LTG), Monotherapy