急性细胞因子与2型糖尿病骨质疏松症关系的研究

急性细胞因子与2型糖尿病骨质疏松症关系的研究

奚悦¹,李敬林²,李德华³,李志强⁴

1. 辽宁医学院附属第三医院
2. 辽宁中医药大学内分泌科
3. 辽宁医学院人体解剖与组织胚胎教研室
4. 辽宁医学院流行病学教研室

收稿日期:2011-08-18 修回日期:2011-11-29 出版日期:2012-02-15 发布日期:2012-02-15
通讯作者: 奚悦

The study of the relationship between Osteoporosis of type 2 diabetes and A-SAA

Received:2011-08-18 Revised:2011-11-29 Published:2012-02-15 Online:2012-02-15

奚悦1 ,李敬林2 ,李德华3 ,李志强4 . 急性细胞因子与2型糖尿病骨质疏松症关系的研究[J]. .

摘要/Abstract

摘要： 摘要目的：初步探讨2型糖尿病骨质疏松症与其相关危险因素之间的关系。方法：对2010年4月至2011年4月间收住于本院住院的100名男性2型糖尿病患者为研究对象。按腰椎骨密度(T值)分为骨量正常组（A组）、低骨量组（B组）和骨质疏松组（C组）；对比3组间患者的年龄、体重指数、病程、血糖、糖化血红蛋白、血脂、急性时相血清淀粉样蛋白A（A-SAA）、UAER、TNF-α、IL-6等指标之间的差异，并进行相关性分析。结果：（1）3组间的年龄、体重指数、病程、糖化血红蛋白、空腹血糖、A-SAA、UAER、TNF-α、IL-6均存在显著性差异(P<0.05)。（2）糖尿病患者骨密度的多因素相关性分析提示BMD与年龄、病程、糖化血红蛋白、A-SAA、UAER、TNF-α、IL-6呈负相关(P均<0.05),与体重指数(BMI)正相关(P<0.05)。结论：高血糖及A-SAA、TNF-α和IL-6水平的增高是发生糖尿病骨质疏松症的危险因素。

关键词: 糖尿病骨质疏松症

Abstract: Abstract Objective: To investigate the relationship between osteoporosis of type 2 diabetes and its association with risk factors preliminarily. Methods: Selected a total of 100 male patients with type 2 diabetes who came to Endocrine department of the third affiliated Hospital of Liaoning Medicine College from April 2010 to April 2011 as the object of study.All the patients were divided into the normal bone quantity group (A group), the low bone quantity group (B group) and the osteoporosis group (C group) according to the lumbar vertebra bone density(The T value). To contrast 3 groups of patient's ages, BMI, disease duration, FPG, glycosylated hemoglobin (HbA1c), the blood fats, A-SAA、UAER, TNF-α, IL-6 and so on, and then carried on the relevant analysis .Results: （1）There was significant difference among threnn groups in the facets of ages, BMI, the course, FPG, glycosylated hemoglobin (HbA1c), the blood fats, A-SAA, UAER, TNF-α and IL-6.（p﹤0.05）.（2）Multivariate correlation analysis of bone mineral density in patients with diabetes showed that BMD had negative correlation with age, disease duration, HbA1c, A-SAA、UAER, TNF-α and IL-6 (p <0.05), but had positive corelation with body mass index (BMI)（p﹤0.05）.Conclusion: High blood sugar and the increased level of A-SAA, TNF-α and IL-6 are the risk factor for osteoporosis of diabetes.

Key words: Osteoporosis of diabetes