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骨龄指数在儿童性早熟诊断中的临床意义

华英   

  1. 天津医科大学总医院儿科
  • 收稿日期:2011-06-14 修回日期:2011-09-19 出版日期:2012-05-15 发布日期:2012-05-15
  • 通讯作者: 华英

The clinical significance of bone age index in the diagnosis of children sexual precocity

HUA Ming   

  • Received:2011-06-14 Revised:2011-09-19 Published:2012-05-15 Online:2012-05-15
  • Contact: HUA Ming

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摘要： 目的：检测性早熟患儿骨龄指数(BAI)与GnRH激发试验各指标之间是否存在相关性。方法：临床诊断为性早熟的38例女童均做GnRH激发试验，摄左手腕部正位片并用CHN法测骨龄，骨龄除以实际年龄得骨龄指数(BAI)，根据临床表现及实验室结果分为特发性中枢性性早熟（ICPP）组及外周性性早熟（PPP）组。并分别对ICPP组和PPP组女童BAI与GnRH激发试验各指标间做相关性分析。结果：ICPP组女童的BAI与LH峰、FSH峰、LH/FSH峰之间存在相关性，而PPP组女童BAI与各指标之间无明显相关性。结论：BAI越大中枢性性早熟可能性越大，越需要做GnRH激发试验。

关键词: 骨龄指数, 性早熟, GnRH激发试验, 儿童, 诊断

Abstract: Objective: To detect the correlation between bone age index (BAI) and index of GnRH stimulation tests for precocious children. Methods: 38 girls who had been diagnosed sexual precocity did GnRH stimulation tests and Bone age be determined by left hand and wrist X-ray, CHN method was used to determine the bone age, BAI equal to the bone age dividing the actual age, according to the clinical symptom and the results of laboratory, the 38 girls were divided into idiopathic precocious puberty (ICPP) group and peripheral precocious puberty (PPP) group. The correlation of BAI and index of GnRH stimulation tests were analyzed between the two groups. Results: the BAI and the LH peak 、FSH peak、LH/ FSH peak ratio had correlation in the idiopathic precocious puberty group ,but in the peripheral precocious puberty group the correlation was not existed. Conclusion: the higher BAI, the more possible to be central precocious puberty, the more necessary to do GnRH stimulation test.

Key words: bone age index, sexual precocity, gonadotropic releasing hormone stimulation test, children, diagnose