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LOX-1对急性冠脉综合征的早期预测价值

王硕莹1,刘相丽1,刘洪梅2,倪燕平1   

  1. 1. 天津医科大学第二医院
    2. 医大二院心内科
  • 收稿日期:2011-10-08 修回日期:2012-02-23 出版日期:2012-07-15 发布日期:2012-07-15
  • 通讯作者: 王硕莹

Value of serum lectin-like oxidize low-density lipoprotein receptor-1 in early prediction of acute coronary syndrome

  • Received:2011-10-08 Revised:2012-02-23 Published:2012-07-15 Online:2012-07-15
  • Contact: shuoying WANG

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摘要： 摘要 目的：通过观察不同类型冠心病患者血中血凝素样氧化低密度脂蛋白受体-1（LOX-1）水平的变化探讨LOX-1对急性冠脉综合征的早期预测价值。 方法：选择行冠脉动脉造影患者75例，根据临床情况分为正常对照组（22例）、不稳定心绞痛组（28例）、急性心肌梗死组（25例），根据SYNTAX积分分为高危组（19例）和低危组（34例）。采用酶联免疫法测定患者血清LOX-1水平。结果：不稳定型心绞痛组和急性心肌梗死组的LOX-1水平分别为86.08±29.93pg/ml和103.93±36.53pg/ml，明显高于正常对照组水平(66.78±23.49pg/ml，P＜0.01或P＜0.05），而且急性心肌梗死组的LOX-1水平也明显高于不稳定型心绞痛组（P＜0.05）。急性心肌梗死组SYNTAX积分为22.88±8.27，明显高于不稳定型心绞痛组（14.79±9.96， P＜0.01）。SYNTAX积分较高的高危组LOX-1水平(107.43±35.18 pg/ml)明显高于低危组（86.90±31.27pg/ml，P＜0.05）。结论：LOX-1是预测急性冠脉综合征的很有潜力的生物学标记物。

关键词: 血凝素样氧化低密度脂蛋白受体-1, 急性冠脉综合征, 易损斑块, SYNTAX评分

Abstract: Abstract Objective: To assess the value of serum lectin-like oxidized low-density lipoprotein receptor-1(LOX-1) in early prediction of acute coronary syndrome(ACS). Methods: Enzyme-linked immunosorbent assay was used to detect the level of serum LOX-1 in 75 patients who underwent coronary angiography, 22 normal control subjects, 28 with unstable angina(UA),25 with acute myocardial infarction(AMI). The SYNTAX score was calculated in all the 53 enrolled ACS patients, 19 patients with high SYNTAX score, 34 patients with low SYNTAX score. Results: The levels of LOX-1 was significantly higher in UA patients (86.08±29.93pg/ml )and AMI patients(103.93±36.53pg/ml) than in normal control subjects （66.78±23.49pg/ml ,P<0.01 or P<0.05).Furthermore, in AMI group, the levels of LOX-1 was significantly higher than in unstable angina group (P<0.05). Higher SYNTAX score was detected in AMI group (22.88±8.27) than in UA group(14.79±9.96, P<0.01). The levels of LOX-1 was significantly higher in patients with high SYNTAX score (107.43±35.18 pg/ml) than those with low SYNTAX score (86.90±31.27pg/ml，P＜0.05 ). Conclusion: LOX-1 might be a promising biomarker for predicting ACS.

Key words: Lectin-like oxidized low-density lipoprotein receptor-1, acute coronary syndrome, vulnerable plaque, SYNTAX score