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低分子肝素预防腹部手术后下肢深静脉血栓形成的临床研究

肖元廷   

  1. 天津市天和医院外科
  • 收稿日期:2012-03-01 修回日期:2012-04-24 出版日期:2012-08-15 发布日期:2012-08-15
  • 通讯作者: 肖元廷

The clinic study of prevention of lower limb deep vein thrombosis by low molecular heparin after abdominal operation

  • Received:2012-03-01 Revised:2012-04-24 Published:2012-08-15 Online:2012-08-15

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摘要： 【摘要】 目的 研究低分子肝素在腹部外科手术后预防下肢深静脉血栓(DVT)形成的应用。方法 选取70例腹部外科手术患者为观察对象，术前检查凝血功能、D2聚体，双下肢血管多普勒。排除栓塞者。接受低分子肝素者为治疗组，术后第一天开始给予低分子肝素4100 u，脐周皮下注射，每天一次，共用3-5天。未接受治疗者为观察组。术后第7-8天行双下肢血管多普勒检查。对比分析两组术后下肢深静脉血栓、伤口渗血的发生率。结果 接受低分子肝素治疗的患者DVT发生率明显低于治疗组（P＜0.05），两组术后出血的发生率无明显差异。结论 低分子肝素在腹部外科手术后预防下肢深静脉血栓形成是有积极作用的，应引起普外科医师的重视。

关键词: 低分子肝素, 腹部外科, 下肢深静脉血栓, 血管多普勒超声

Abstract: 【Abstract Objective】To explore the role of low molecular heparin in prevention of lower limb deep vein thrombosis (DVT) after abdominal operation. Methods we selected 70 cases who underwent abdominal operations, pre-operation exam included blood coagulation function, D2 polymer, bilateral low limbs vascular Doppler scanning. Those with thrombosis were excluded. The cases receive low molecular heparin were treatment group, which was given low molecular heparin 4100u, priumbilical subcutaneous injection, one daily, all for 3-5days. The rest without receiving low molecular heparin were the observation group. In post-operative day 7 or 8, all cases received bilateral low limbs vascular Doppler scanning. In both group, the rate of DVT and wound oozing were compared. Result the rate of DVT in treatment group was much lower than that of conversation group(P<0.05), the rate of wound oozing had no obvious difference. Conclusion in prevention of low limb deep vein thrombosis the low molecular heparin acts actively, we should pay more attention.

Key words: Low molecular heparin, Abdominal operation, Low limb deep vein thrombosis, Vascular Doppler scanning.