关键词: 花生四烯酸, 血小板聚集, 阿司匹林, 阿司匹林, 手术期间, PAgT, 尿11-脱氢-TXB2

Abstract:   [Abstract] Objective   To investigate the reasonable time limit for stopping the aspirin treatment in preoperative patients with general surgery and the effects on platelet function in postoperative patients with recovering the therapy of aspirin.Methods   A total of121patients undergoing elective general surgery were divided into stopping aspirin treatment5d group(n=59) and stopping aspirin treatment 7d group (n=62). Fifty healthy volunteers were used as the control group. The arachidonic acid (AA)-induced platelet aggregation test was used to detect the platelet agglutination rate in all groups. Aspirin was reused24~48h after surgery. The level of urinary11-dehydro- thromboxane B2 (11-DH-TXB2) was assayed by ELISA 7 and10d after retreatment. Results   The levels of the PAgT (5min,8min and10min) were decreased significantly in patients with stopping aspirin treatment 5d group compared with those of patients with stopping aspirin treatment7d group and control group (P<0.05). There was no significant difference in the level of PAgT between patients with stopping aspirin treatment7d group and control group. The platelet aggregation showed two different characteristic curves after stopping aspirin treatment for5d. And the normal curve of platelet aggregation was found after stopping aspirin treatment for7d. The levels of PAgT and urinary11-DH-TXB2were significantly lower in patient recovered the aspirin treatment for7d and10d than that of control, and which was significantly higher in 7d group than that of10d group (P>0.05). Conclusion   The platelet aggregative function returned to normal level in patients with7-d preoperative stopping aspirin. The laboratory monitoring of aspirin therapy should be more than7d after postoperative reusing aspirin

Key words: arachidonic acid, platelet aggregation, aspirin, ASPIRIN, intraoperative period, platelet agglutination rate test, 11-dehydro- thromboxane B2