脂肪酸逆转局麻药心肌毒性的药理机制研究进展

脂肪酸逆转局麻药心肌毒性的药理机制研究进展

高晶¹,刘超²

1. 天津医科大学第二医院麻醉科
2. 天津医科大学第二医院放射科

收稿日期:2013-12-02 修回日期:2014-02-26 出版日期:2014-07-15 发布日期:2014-07-15
通讯作者: 刘超

Progress in Pharmacological Mechanism for the Role of Fatty Acid in Reversal of Myocardial Toxicity of Local Anesthetics

Received:2013-12-02 Revised:2014-02-26 Published:2014-07-15 Online:2014-07-15

高晶1 ,刘超2 . 脂肪酸逆转局麻药心肌毒性的药理机制研究进展[J]. .

摘要/Abstract

摘要：

【摘要】目前尚没有特异的局麻药解毒剂，严重阻碍了临床治疗效果，寻找有效的局麻药解毒剂日益紧迫。本文从脂肪池、能量代谢、NO、离子通道和增溶作用来诠释脂肪酸逆转局麻药心肌毒性的分子药理学机制，并比较了纳米脂质体与普通脂肪乳剂结构和功能上的不同的特点。

关键词: 纳米脂质体, 局麻药, 心肌毒性, 药理机制

Abstract: [Abstract] At present, there is no specific antidote for local anesthetic toxicity, which seriously hindered therapeutic efficts of clinical treatment. It is increasingly urgent for finding find the effective antidote to local anesthetic. This article at? tempts to interpret the molecular pharmacological mechanism from fat pool, energy metabolism, NO, ion channel and solubili? zation for the role of fatty acids in reversal of myocardial toxicity of local anesthetics. And the different characteristics of the structure and function of nano liposome and fat emulsion were compared.

Key words: nano-liposomes, local anesthetics, myocardial toxicity, pharmacological mechanism