天津医药 ›› 2018, Vol. 46 ›› Issue (10): 1135-1139.doi: 10.11958/20180698

• 综述 • 上一篇    下一篇

心型脂肪酸结合蛋白在心血管疾病中的作用

王翠华 1,刘衍恭 2,郑明奇 1△   

  1. 基金项目:河北省科技计划项目(16277707D);河北省自然科学基金面上项目(H2015206386);河北省医学科学研究重点课题计划 (20150191) 作者单位:1河北医科大学第一医院心脏中心(邮编050031);2日本大分大学病态生理研究室 作者简介:王翠华(1983),女,硕士在读,主治医师,主要从事心血管内科方面研究 △通讯作者 E-mail: mzheng2020@163.com
  • 收稿日期:2018-05-02 修回日期:2018-07-02 出版日期:2018-10-15 发布日期:2018-11-09
  • 通讯作者: 郑明奇 E-mail:mzheng2020@163.com
  • 基金资助:
    河北省科技计划项目;河北省自然科学基金面上项目;河北省医学科学研究重点课题计划

The role of heart-type fatty acid-binding protein in cardiovascular diseases

WANG Cui-hua1, LIU Yan-gong2, ZHENG Ming-qi1△   

  1. 1 Heart Center, the First Hospital of Hebei Medical University, Shijiazhuang 050031, China; 2 Department of Pathophysiology, Oita University School of Medicine, Japan △Corresponding Author E-mail: mzheng2020@163.com
  • Received:2018-05-02 Revised:2018-07-02 Published:2018-10-15 Online:2018-11-09
  • Contact: ZHENG Mingqi E-mail:mzheng2020@163.com

摘要: 摘要:心型脂肪酸结合蛋白(H-FABP)是小分子蛋白质,主要在心脏中表达,在长链脂肪酸进入线粒体进行β氧 化时起着关键的作用。目前临床上H-FABP用于持续的心肌损伤及急性心肌梗死(AMI)早期诊断标志物,越来越多 的研究表明,H-FABP与急性冠脉综合征、心力衰竭、心律失常等疾病的诊断和预后有密切关系。

关键词: 心血管疾病, 心律失常, 心性, 心力衰竭, 诊断, 预后, 心型脂肪酸结合蛋白, 急性心肌梗死

Abstract: Abstract: Heart-type fatty acid-binding protein (H-FABP) is a small molecular protein, which is mainly expressed in heart and plays a key role in mitochondrial β oxidation through partitioning of long-chain fatty acids toward the mitochondria. Nowadays, H-FABP is clinically used for the early diagnosis of persistent myocardial injury and acute myocardial infarction (AMI). More and more studies have showed that H-FABP is closely related to the diagnosis and prognosis of acute coronary syndrome, heart failure and arrhythmia.

Key words: cardiovascular diseases, arrhythmias, cardiac, heart failure, diagnosis, prognosis, heart-type fatty acidbinding protein, acute myocardial infarction