天津医药

天津医药 ›› 2018, Vol. 46 ›› Issue (2): 175-177.doi: 10.11958/20171329

• 临床研究 • 上一篇    下一篇

甲状腺髓样癌18 F-FDG PET/CT表现

郑红娜， 解敬慧， 朱毅， 张延军△   

  1. 大连医科大学附属第一医院核医学科 （邮编116021）
  • 收稿日期:2017-11-24 修回日期:2017-12-28 出版日期:2018-02-15 发布日期:2018-02-15
  • 通讯作者: 郑红娜 E-mail:zhenghongna@126.com

Manifestation of medullary thyroid carcinoma on 18 F-FDG PET/CT

ZHENG Hong-na, XIE Jing-hui, ZHU Yi, ZHANG Yan-jun△   

  1. Department of Nuclear Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian 116021, China
  • Received:2017-11-24 Revised:2017-12-28 Published:2018-02-15 Online:2018-02-15

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摘要： 摘要： 目的 探讨甲状腺髓样癌 （MTC） 的18 F-氟脱氧葡萄糖 （18 F-FDG） 正电子发射断层显像/X 线计算机体层成像 （PET/CT） 特征， 以提高其术前诊断水平。方法 回顾性分析经手术病理证实的 7 例 MTC 患者的18 F-FDG PET/CT 图像表现及临床资料。测量原发灶早期及延迟最大标准摄取值 （SUVmaxE 和 SUVmaxD ）， 计算储留指数 （RI）。结果 7 例 MTC 患者中， 单发 4 例， 双发 2 例， 多发病灶 1 例； 形态不规则 4 例； 边界不清楚 4 例； 密度不均匀减低 7 例； 伴粗大钙化 5 例。2 例患者原发灶早期显像表现为 FDG 摄取较低， SUVmaxE 分别为 2.5、 2.1， 延迟显像代谢活性下降， RI 为-20%、 -14.3%； 余 5 例早期显像及延迟显像均表现为 FDG 不均匀代谢增高， SUVmaxE 为 3.6~9.1， 平均 5.8±2.1， RI 为 7.5%~45.8%， 平均 21.3%±16.2%。伴颈部淋巴结转移 5 例， 早期显像及延迟显像均表现为 FDG 不同程度代谢增高， SUVmaxE 为 3.2~8.2， SUVmaxD 为 3.3~9.8； 所有 7 例均不伴有远处转移。结论 18 F-FDG PET/CT 有助于检出 MTC 及判断肿瘤生物学行为和全面评估转移情况。

关键词: 关键词： 正电子发射断层显像术, 体层摄影术, X 线计算机, 氟脱氧葡萄糖F18, 诊断, 鉴别, 甲状腺髓样癌

Abstract: Abstract: Objective To investigate the 18 F-FDG PET / CT features of medullary thyroid carcinoma (MTC), and to improve its diagnosis preoperatively. Methods Data of 18 F-FDG PET/CT findings and clinical materials of 7 patients with MTC confirmed by pathology were retrospectively analyzed. SUVmaxE and SUVmaxD were measured in primary tumor, and retention index (RI) was calculated. Results There were four patients with single lesion, two patients with double lesions, one patient with multiple lesions, four patients with lesions of irregular shape, four patients with lesions of unclear border, seven patients with lesions of uneven decreased density and five patients with calcifications in lesions. Uptake of 18 F-FDG in primary tumor was lower in 2 patients, their SUVmaxE values were 2.5 and 2.1 respectively, and RI values were -20%and -14.3% respectively. The other five patients showed higher metabolism in both early and delayed imaging, and SUVmaxE was 3.6-9.1 with an average of 5.8±2.1. RI was 7.5%-45.8% with the average of 21.3%±16.2%. There were five patients with cervical lymph node metastasis. The high metabolism was found in both early and delayed imaging of FDG. The ranges of SUVmaxE and SUVmaxD were 3.2-8.2 and 3.3-9.8 respectively. None of 7 patients showed distant metastasis. Conclusion 18 F-FDG PET/ CT is helpful for identifying MTC and providing information about biological behavior and evaluating metastasis of MTC.

Key words: Key words：positron-emission tomography, tomography, X-ray computed, fluorodeoxyglucose F18, diagnosis, differential, positron emissiontomography