天津医药 ›› 2017, Vol. 45 ›› Issue (11): 1187-1190.doi: 10.11958/20170747

• 临床研究 • 上一篇    下一篇

甲状腺乳头状癌超声弹性成像与血清学指标的关系

丁关保,俞秋雨,方开锋   

  1. 安徽省宿州市皖北煤电集团总医院超声科
  • 收稿日期:2017-06-28 修回日期:2017-09-16 出版日期:2017-11-15 发布日期:2017-11-15
  • 通讯作者: 俞秋雨 E-mail:qiuyu234@126.com

Relationship of ultrasonic elastography and serologic indexes in patients with papillary thyroid carcinoma#br#

DING Guan-bao,YU Qiu-yu,FANG Kai-feng   

  1. Department of Ultrasound,Wanbei Coal-electricity Group General Hospital
  • Received:2017-06-28 Revised:2017-09-16 Published:2017-11-15 Online:2017-11-15

摘要: 目的 测定甲状腺乳头状癌超声弹性评分(ES)和弹性系数(SR),并分析其与血清学相关指标的关系。方法 甲状腺肿瘤患者 106 例经组织病理学检查分为甲状腺乳头状癌组(n=56)和甲状腺腺瘤组(n=50);另取同期于本院体检的甲状腺功能正常者作为对照组(n=50)。采用彩色超声诊断仪检测 3 组 ES 和 SR;采用电化学发光法测定血清促甲状腺激素(TSH)、甲状腺球蛋白抗体(TgAb)、过氧化物酶抗体(TpoAb);采用全自动型电化学发光检测仪测定血清半乳糖血凝素-3(Gal-3)、血管内皮生长因子(VEGF)、细胞角蛋白 19 片段(Cyfra21.1)。结果 正常对照组、甲状腺腺瘤组及甲状腺乳头状癌组的 ES、SR,血清 Gal-3、VEGF、Cyfra21.1 水平均依次增高(P<0.05);甲状腺乳头状癌组血清 TSH、TgAb、TpoAb 高于甲状腺腺瘤组、正常对照组(P<0.05),但后 2 组间 3 指标差异无统计学意义(P>0.05)。甲状腺乳头状癌患者的超声 ES、SR 与血清 TSH、TgAb、TpoAb、Gal-3、VEGF、Cyfra21.1 呈正相关(P<0.05)。结论 甲状腺乳头状癌超声 ES、SR 升高,且与相关血清学指标存在相关,可用于甲状腺乳头状癌的辅助诊断。

关键词: 甲状腺乳头状癌, 超声弹性成像, 弹性评分, 弹性系数, 血清指标

Abstract: Objective To evaluate the elastic score (ES) and strain ratio (SR) in papillary thyroid carcinoma patients,and analyse their relationship with serologic index. Methods Totally one hundred and six patients with thyroid neoplasm were divided into papillary thyroid carcinoma group (n=56) and thyroid adenoma group ( n=50) according to histopathology results. Another fifty cases of healthy people were chosen as normal control group at the same period. The ES and SR were evacuated by color Doppler ultrasonic diagnostic apparatus in three groups of patients. Thyroid stimulating hormone (TSH),thyroglobulin antibody (TgAb), and thyroid peroxidase antibody (TpoAb) were detected by electrochemiluminescence immunoassay. Data of galectin-3 (Gal-3), vascular endothelial growth factor (VEGF), and cytokeratin 19 fragment (Cyfra21.1) were tested by automatic optical inspection. Results Indexes of ES, SR, Gal-3, VEGF and Cyfra21.1 showed statistically increasing tendency in the control group, thyroid adenoma group and papillary thyroid carcinoma group sequentially (P<0.05). Serum levels of TSH, TgAb and TpoAb were significantly higher in the papillary thyroid carcinoma group than those in the other two groups (P<0.05). And there were no significant differences in serum TSH, TgAb and TpoAb between the control group and thyroid adenoma group (P>0.05). There were positive correlation between ES, SR and TSH, TgAb, TpoAb, Gal-3, VEGF, Cyfra21.1 in patients with papillary thyroid carcinoma (P<0.05). Conclusion Papillary thyroid carcinoma shows increased ES and SR detected by ultrasound, and which are relevant to related serological indicators. The two indices may be used for auxiliary diagnosis of papillary thyroid carcinoma.

Key words: papillary thyroid carcinoma, elastosonography, elastic score, strainratio, serum index

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