天津医药 ›› 2018, Vol. 46 ›› Issue (2): 211-215.doi: 10.11958/20170954

• 综述 • 上一篇    下一篇

肩袖损伤生物学修复的研究进展

王增亮1 , 许海委2△, 栾雅静3△, 徐宝山2 , 杨强2 , 陈德生1   

  1. 1天津市天津医院运动损伤与关节镜一病区 (邮编300211), 2微创脊柱外科; 3天津医科大学基础医学院教学中心
  • 收稿日期:2017-09-11 修回日期:2017-12-02 出版日期:2018-02-15 发布日期:2018-02-15
  • 通讯作者: 许海委 E-mail:mrxvhaiwei@163.com
  • 基金资助:
    CS-胶原改性的PCL/脱细胞髓核基质仿生支架联合人脐带间充质干细胞构建组织工程椎间盘;动态力学刺激对纤维环-髓核组织工程化构建的影响;仿生斜交叠层结构的纳米PCL/SF纤维环支架复合人脐带间充质干细胞修复纤维环缺损;含软骨钙化层结构的仿生诱导支架联合人脐带间充质干细胞构建组织工程骨软骨;明胶海绵和丝素复合自体骨髓干细胞修复椎间盘手术缺损;明胶海绵和丝素复合自体骨髓干细胞修复椎间盘手术缺损;趋化诱导功能骨软骨支架促MSC归巢及修复骨软骨缺损

Research progress on biologic repair of rotator cuff injury

WANG Zeng-liang1 , XU Hai-wei 2△, LUAN Ya-jing3△, XU Bao-shan2 , YANG Qiang2 , CHEN De-sheng1   

  • Received:2017-09-11 Revised:2017-12-02 Published:2018-02-15 Online:2018-02-15
  • Contact: Hai-Wei XU E-mail:mrxvhaiwei@163.com

摘要: 摘要: 肩袖损伤是一种临床常见的肩关节疾病, 可导致患者肩关节疼痛、 活动受限、 生活质量下降。目前的治疗方法存在一定的局限性, 常导致修复失败或肩袖再次撕裂, 因此需要寻求一种新的、 更加理想的修复方法。生物学修复的出现为肩袖损伤提供了一种新的治疗方法, 有望恢复肩袖的正常组织结构。生物学修复包括应用生长因子和/或细胞促进肩袖肌腱再生, 本文就生物学修复在肩袖损伤方面的研究进展作一综述。

关键词: 关键词: 干细胞, 生长因子, 肩袖损伤, 生物学修复, 综述

Abstract: Abstract: Rotator cuff injury is a common shoulder disease, which often results in pain and limited motion of shoulder and reduces the quality of life. There are some limitations for current treatments, which often lead to repair failure or reinjury of rotator cuff. Therefore, a novel repair technique is needed. Biologic repair represents a novel technique in the management of rotator cuff injury, and has the potential to restore the normal histological structure of rotator cuff. Biologic repair involves the application of growth factors and/ or cells to promote the regeneration of rotator cuff tendons. This study reviewed the literatures on biologic repair of rotator cuff injury, and presented the research progress.

Key words: Key words: stem cells, growth factor, rotator cuff injury, biologic repair, review