天津医药 ›› 2020, Vol. 48 ›› Issue (5): 460-464.doi: 10.11958/20193425

• 综述 • 上一篇    

肠道菌群及其代谢产物与心血管疾病关系的研究进展 #br#

霍星宇,耿婕
  

  1. 天津市胸科医院心内科(邮编300222
  • 收稿日期:2019-11-12 修回日期:2020-02-22 出版日期:2020-05-15 发布日期:2020-06-24
  • 通讯作者: 耿婕 E-mail:gengjie_1973@126.com

Progress in the relationship between intestinal flora and its metabolites with cardiovascular diseases #br#

HUO Xing-yu, GENG Jie△ #br#   

  1. Department of Cardiology, Tianjin Chest Hospital, Tianjin 300222, China
  • Received:2019-11-12 Revised:2020-02-22 Published:2020-05-15 Online:2020-06-24

摘要: 心血管疾病作为目前致死致残率较高的疾病,时刻威胁着人类的健康。近年来,随着研究的不断进展,有
报道称肠道菌群及其代谢产物也参与到心血管疾病(包括与动脉粥样硬化、心力衰竭、高血压等)发生发展的过程
中。通过改善肠道菌群及其代谢产物的组成,可以改善心血管疾病的进程,而这种治疗方法也成为了一个治疗心血
管疾病的新方向。本文就肠道菌群的组成,肠道菌群代谢产物的作用,肠道菌群及其代谢产物与动脉粥样硬化、心
力衰竭、高血压等疾病的关系,通过改善肠道菌群进行疾病治疗等的研究现状进行综述。

关键词: 胃肠道微生物组;冠状动脉疾病;心力衰竭;脂肪酸类, 挥发性;综述

Abstract: Cardiovascular disease, as a disease with high mortality and disability rates, is a constant threat to human
health. In recent years, with the continuous development of research, it has been reported that intestinal flora and its
metabolites are also involved in the occurrence and development of cardiovascular diseases (including atherosclerosis, heart
failure and hypertension). By improving the composition of intestinal flora and its metabolites can improve the progression of
cardiovascular diseases. This treatment has become a new target for the treatment of cardiovascular diseases. In this paper,
the composition of intestinal flora, the role of intestinal flora metabolites and the relationship between intestinal flora and its
metabolites and atherosclerosis, heart failure, hypertension and other diseases were reviewed.

Key words: gastrointestinal microbiome, coronary artery disease, heart failure, fatty acids, volatile, review

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