天津医药

天津医药 ›› 2020, Vol. 48 ›› Issue (11): 1119-1124.doi: 10.11958/20201235

• 综述 • 上一篇    下一篇

蛋白翻译后修饰与肠易激综合征

王玥梅1，朱远冰1，吴巧凤1,2,3△   

  1. 1成都中医药大学针灸推拿学院（邮编610075），2针灸与内稳态研究所；3针灸与时间生物学四川省重点实验室
  • 收稿日期:2020-05-04 修回日期:2020-06-11 出版日期:2020-11-15 发布日期:2020-11-15

Post-translational modifications of proteins and irritable bowel syndrome

WANG Yue-mei1, ZHU Yuan-bing1, WU Qiao-feng1, 2, 3△   

  1. 1 Acupuncture and Moxibustion College, 2 Institute of Acupuncture & Homeostasis, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China; 3 Acupuncture & Chronobiology Key Laboratory of Sichuan Province
  • Received:2020-05-04 Revised:2020-06-11 Published:2020-11-15 Online:2020-11-15

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摘要： 蛋白翻译后修饰作为蛋白质功能调节的一种重要方式，主要由识别特定蛋白质中特定靶序列的酶催化，影响蛋白的活性、稳定性、定位等不同方面，与许多重要的生命活动密切相关。肠易激综合征（IBS）是一种胃肠道功能紊乱性疾病，其发病机制仍未完全明确。已有研究表明多种蛋白翻译后修饰如乙酰化、磷酸化、甲基化、糖基化等在IBS的发生发展中起重要作用。本文就几种主要蛋白修饰类型及其在IBS中作用的研究进展进行概述。

关键词: 蛋白质修饰, 转译；肠易激综合征；乙酰化作用；甲基化；糖基化；磷酸化

Abstract: Post-translational modifications of proteins, as an important way to regulate protein function, are mainly catalyzed by enzymes that recognize specific target sequences in specific proteins. It affects different aspects of protein stability and activity, and is closely related to many important life activities. Irritable bowel syndrome (IBS) is a gastrointestinal dysfunction disorder, and its pathogenesis has not been fully clarified. Studies have shown that many post-translational modifications of proteins, such as acetylation, phosphorylation, methylation and glycosylation, play an important role in the development of IBS. This article summarizes several major protein modification types and their current research progress in IBS.

Key words: protein modification, translational, irritable bowel syndrome, acetylation, methylation, glycosylation, phosphorylation