天津医药

天津医药 ›› 2021, Vol. 49 ›› Issue (5): 545-549.doi: 10.11958/20202913

• 综述 • 上一篇    下一篇

银屑病角质形成细胞增殖机制的研究进展

孙冷冰1，2，龚坚1，刘巧3△   

  1. 1江西中医药大学（邮编330004）；2海南省第五人民医院；3江西中医药大学第二附属医院
  • 收稿日期:2020-10-22 修回日期:2021-01-07 出版日期:2021-05-15 发布日期:2021-05-25
  • 通讯作者: 孙冷冰 E-mail:504160761@qq.com
  • 基金资助:
    国家自然科学基金资助项目（81860848）；国家重点研发计划“中医药现代化研究”重点专项（2018YFC1705300）；江西中医药大学一流学科建设科研启动基金项目（JXSYLXK-ZHYI011，JXSYLXK-ZHYI046）

Research progress on the proliferation mechanism of keratinocytes in psoriasis

SUN Leng-bing1,2, GONG Jian1, LIU Qiao3△   

  1. 1 Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China; 2 the Fifth People's Hospital of 
    Hainan Province; 3 the Second Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine
  • Received:2020-10-22 Revised:2021-01-07 Published:2021-05-15 Online:2021-05-25
  • Contact: SUN lengbing E-mail:504160761@qq.com

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摘要： 摘要：银屑病的发病机制极其复杂，角质形成细胞（KCs）异常增殖是其重要的病理特征之一。在致病过程中，诸多因素可引起KCs增殖，且各因素间相互影响致使银屑病反复发作，难以治愈。本文从炎性细胞因子、氧化应激、微小RNA以及中医药拮抗KCs增殖等方面进行综述，为深入研究银屑病的发病机制及临床精准治疗提供参考。

Abstract: Psoriasis is a common chronic inflammatory skin disease. Its pathogenesis is extremely complex. Abnormal proliferation of keratinocytes (KCs) is one of its important pathological features. In the process of pathopoiesis, many factors can cause keratinocytes proliferation，interacting with each other, thus leading to the recurrence of psoriasis and the fact that it is more difficult to cure. In this paper, we focus on inflammatory cytokines, oxidative stress, microRNA and the antagonism of traditional Chinese medicine on keratinocytes proliferation looking forward to provide reference for further study of pathogenesis and clinical precise treatment of psoriasis.