天津医药

天津医药 ›› 2021, Vol. 49 ›› Issue (7): 747-751.doi: 10.11958/20210408

• 临床研究 • 上一篇    下一篇

丹红注射液治疗CKD伴低氧血症COPD患者的临床疗效观察

何媛，李冬生，李月红   

  1. 1天津市中西医结合医院呼吸与危重症医学科（邮编300100），2肾脏内科
  • 收稿日期:2021-02-20 修回日期:2021-05-05 出版日期:2021-07-15 发布日期:2021-07-12
  • 作者简介:何媛（1978），女，博士，副主任医师，主要从事呼吸系统疾病的中西医结合基础与临床研究。E-mail：heyuan_1101@163.com

Clinical observation of Danhong injection in the treatment of chronic obstructive pulmonary disease with CKD and hypoxemia

HE Yuan, LI Dong-sheng, LI Yue-hong   

  1. 1 Department of Respiratory and Critical Care Medicine, 2 Department of Nephrology, Tianjin Hospital of ITCWM Nankai Hospital, Tianjin 300100, China
  • Received:2021-02-20 Revised:2021-05-05 Published:2021-07-15 Online:2021-07-12

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摘要： 目的　探究丹红注射液联合常规治疗用于慢性肾脏疾病（CKD）伴低氧血症慢性阻塞性肺疾病（COPD）患者的临床疗效。方法　回顾性分析CKD伴低氧血症COPD患者的病例资料，其中常规治疗组和丹红注射液组各50例。常规治疗组进行常规利尿消肿、抗炎、止咳化痰、解痉平喘等对症等治疗。丹红注射液组在常规治疗的基础上静脉滴注丹红注射液14 d。比较2组患者治疗前后血气分析结果、肾功能及肝功能变化情况。评价治疗前后中医证候总积分、治疗有效率、低氧血症改善情况和治疗安全性。结果　治疗后与常规治疗组比较，丹红注射液组动脉血氧分压［p（O2）］）升高，动脉血二氧化碳分压［p（CO2）］、β2微球蛋白、血清胱抑素C、中医证候总积分降低（P＜0.05）。丹红注射液组治疗后尿素氮（BUN）、血β2微球蛋白、血清胱抑素C和中医证候总积分均较治疗前降低（P＜0.05）。丹红注射液组疗效优于常规治疗组（Z=2.268，P＜0.05）。且丹红注射液组低氧血症改善率（56.00%）较常规治疗组（30.00%）提高（χ2=4.889，P＜0.05）。治疗前后2组的组内和组间肝功能相关指标差异均无统计学意义（P＞0.05）。结论　丹红注射液可改善CKD伴低氧血症COPD患者肾功能、缺氧环境及临床症状。

关键词: 肾疾病, 慢性病, 肺疾病, 慢性阻塞性, 低氧, 血瘀, 丹红注射液

Abstract: Objective　To study the clinical effect of Danhong injection combined with conventional treatment in chronic kidney disease (CKD) with hypoxemia chronic obstructive pulmonary disease (COPD). Methods　Clinical data of CKD patients with hypoxemian COPD were retrospectively analyzed. There were 50 cases in the conventional treatment group and 50 cases in the Danhong injection group. The conventional treatment group was given the treatment of diuresis, detumescence, anti-inflammation, cough and phlegm, anti-spasmodic and anti-asthma. The Danhong injection group was given intravenous Danhong injection for 14 days on the basis of conventional treatment. Before and after the treatment, the change of indexes including arterial blood gas analysis, renal function and liver function were compared between the two groups. The total score of traditional Chinese medicine (TCM) syndromes, the effective rate of treatment, the improvement of hypoxemia and the safety of treatment were evaluated before and after treatment. Results　After treatment, compared with the conventional treatment group, p(O2) was increased in Danhong injection group, while p(CO2), blood β2, CYS-C and the total score of TCM syndromes were decreased in Danhong injection group (P＜0.05). In the Danhong injection group, blood urea nitrogen (BUN), β2-MG, CYS-C and the total score of TCM syndromes were decreased after treatment (P＜0.05). The therapeutic effect of Danhong injection group was superior than that of conventional treatment group (Z=2.268, P＜0.05). The improvement rate of hypoxemia was significantly higher in the Danhong injection group (56.00%) than that in the conventional treatment group (30.00%, χ2=4.889, P＜0.05). There were no significant differences in related indexed of liver function before and after treatment between the two groups (P＞0.05). Conclusion　Danhong injection can improve renal function, hypoxic environment and clinical symptoms in CKD patients with hypoxemia COPD.

Key words: kidney diseases, chronic disease, pulmonary disease, chronic obstructive, hypoxia, blood stasis, Danhong injection